ID   E6R6M8_CRYGW            Unreviewed;      1031 AA.
AC   E6R6M8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Spliceosome complex protein, putative {ECO:0000313|EMBL:ADV22373.1};
GN   OrderedLocusNames=CGB_E1530C {ECO:0000313|EMBL:ADV22373.1};
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22373.1, ECO:0000313|Proteomes:UP000007805};
RN   [1] {ECO:0000313|EMBL:ADV22373.1, ECO:0000313|Proteomes:UP000007805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WM276;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 0:0-0(2011).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       {ECO:0000256|ARBA:ARBA00037272}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family.
CC       {ECO:0000256|ARBA:ARBA00008644}.
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DR   EMBL; CP000290; ADV22373.1; -; Genomic_DNA.
DR   RefSeq; XP_003194160.1; XM_003194112.1.
DR   AlphaFoldDB; E6R6M8; -.
DR   GeneID; 10190238; -.
DR   KEGG; cgi:CGB_E1530C; -.
DR   VEuPathDB; FungiDB:CGB_E1530C; -.
DR   eggNOG; KOG2047; Eukaryota.
DR   HOGENOM; CLU_007736_1_0_1; -.
DR   OrthoDB; 1130725at2759; -.
DR   Proteomes; UP000007805; Chromosome E.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR   PANTHER; PTHR11246:SF5; PRE-MRNA-SPLICING FACTOR SYF1; 1.
DR   SMART; SM00386; HAT; 10.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 3.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022728};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   REGION          346..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          949..971
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1006..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  117201 MW;  77A180D0EE87FCB5 CRC64;
     MASTSLVDTL TSYFPLTLPI PTPITHPHLI PPADLPVEED LLHNPENLRS WLSYIHNVKE
     KIAANEPAKS GVISPEEEIL GPLASKNARD GLQRLVSIYE RAIAVFPTSY KLWKAYYLTR
     QSYVLGELTN DAKEARSQQA KRGAAYKTNV RELLDGAEEA HEWTGGLDPV VGYAEWRSLI
     AAGERMIMCL PNLPIPWLLH LGVLLHPKCP SVFKNGSYAR RTFDRALRTL PPSLHGRVWG
     LYLRWAEVIG GDAGERVWRR YLKVDPSLTE RHITYLLEAD EPRPLAAAKY LLSIARRAQQ
     NLYSSLEGKS PYQLFVDFLE LVEKYADQTG MDEEETLELQ KTKRAVEEKV DGEQPPVEEQ
     EQQSQEEPAS VNGRLMRIAG PPVPLEQGKL FKPTNATSAQ APTQLTYDED TDPSNSRLLD
     VEGIVERDGL QVYKDQAGRL WTGLATYWIK KGEFERASAT FEKGLAAVVT IRDFTQIFDA
     YAEFSETMIS TLMDALADED NLEDEDFDAE ETEQELDERM KSFEELMDRR PFLVNDVLLR
     RNPNEVVEWE KRIALHGNDD AKVVETYVKA LDIINPRKAT GPLYPLYVNF AKFYEEGGSK
     DDNGEPKNEP DLKQARKIFE RAVKVPFKAV DELAEVWCEW AEMELRNENY EEAIRLMQRA
     TTVPKNTKIN YYDDNIPPQS RLFKSLKLWS YYSDLEESIG TVESTKAVYD KIMELKIANA
     QVIVNYATFL EENKYFEESF KVYERGIELF HFPIAFEIWN IYLSKFVKRY GGKKLERARD
     LFEQALENCP EKFCKPLYLM YAKLEEEHGL AKRAMGIYDR AASTVQDSDK FEMYTIYIAK
     ATANFGLPAT RPIYERALES LPDKQTAEMC RRFARMERKL GEIDRARAIY AHASQFCDPR
     VEPEFWQEWN DFEIDTGSED TFREMLRIKR AVQASFNTET SFIAAQAAAA SKGTEKPTDA
     SAQEAQEAAD PMAAMERELN AVGADGARKG GAPAFVASTL NKTNANGIDE GGKEAGEVAN
     PDAIVMDEDE F
//