ID E6RBG3_CRYGW Unreviewed; 1295 AA.
AC E6RBG3;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rho guanyl-nucleotide exchange factor, putative {ECO:0000313|EMBL:ADV24149.1};
GN OrderedLocusNames=CGB_H5630C {ECO:0000313|EMBL:ADV24149.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24149.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV24149.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
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DR EMBL; CP000293; ADV24149.1; -; Genomic_DNA.
DR RefSeq; XP_003195936.1; XM_003195888.1.
DR GeneID; 10185906; -.
DR KEGG; cgi:CGB_H5630C; -.
DR VEuPathDB; FungiDB:CGB_H5630C; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001251_5_0_1; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000007805; Chromosome H.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
FT DOMAIN 471..658
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 859..1156
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 51..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1212
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1295 AA; 144581 MW; 1A3284D858CA707C CRC64;
MPRLPSGPTQ AFPVGAMTPA QAYQASQGHP SSSVVFPRPS TASAAIPAQA TQNIGTPFDP
SSSVTSFSTT NSATSRIPTS TSITSFHKPT SQSPSLAEMS KERSATPDYI GKMGQLAPLS
PAASPTYDTV SSPTTPTGDM SFHARASTDS TVSLPLPLHT TESLPPGARR GYENRSTSFS
GSSREVIRPL SNPAAGLSNP QGQIQTRAPL PSLYPALLSL VSAAFKSYIP LADLTKDGIT
YKDSFSGQAA VTLIAELIKT SDRNLALLLG RSLDAQKFFH DVTYDHRLRD NPKEVYRFRD
RLAAPFTDTN GNGESSTSDE RLTRNGSGAS STGMGFGGGL KALTAARAAD SSSTMHTEST
PVSTTPSRSS TMPFPDSESP DSLDSEDSLP VGVFTLLTDC YSPTCSRDSL CYSINCPRRL
EQMKRLNMKP EPGLNRKLSR ESLVDVKETG TLWIHSVSQE ILDSVDDKEK KRQEAINEVI
YTERDFVRDL EYLRDSWVKP LRTQDVIDAK RRDDFVRQVF WNVHDVLSVN YVLAERLTKR
QKKEPVVSRI GDIFLERVPL FEPFVTYGAH QLFGKYEFEK EKGANAVFQK FVDDTERKPE
SRKLELNGYL TKPITRLGRY PLLLEAVLKY TPDDHPDKED LPEVIKMIKG FLTKVNAESG
KSENIFELAQ IEQQLVFRPN ERIDLRLRDK NRQLVHKGPL KRRGGNREEI ADLLGFLFDH
AFLLVKPKWV NKSEQYKVYR RPIPLELLVL ITPDEQYNSG KLSYGNARSR LITRHPNSKT
NHVSQNNSIT APPKPESKHG FSLTILHLGK KGYSMQLWVD THIGRKKWLE CIDKQQGMLR
EKSTVFVSET ITEGILSGVR KVNCSSPYDQ GNRMIFGTDE GVYFANLRDE KLREPVKVIN
LIDVTQVDVI EEFQLLIVLH ERCVTTFPLD SLDPSDPNAA LKRGKRISSH TSFIKSGICL
GKTLVAIVKS STLSSTIKVM EPVDLSQNRK KTQAGFMRRL NGKDDALKLF KEFYIPTESS
SVHFLKTKLC VGCTKGFEIV DLETLDMQGL LDPSDGSLDF VLKRDNVRPI AIYRIEEDFL
LCYDEFAFYV NKNGWRSRPK WAIVWEGVPT SFALQYPYVI AFEPTFIEVH HVETGHLVQI
IPGNNIQCLF ADTPPSRVNA PLPPNRMMYL PPTPGAPPYT RPPNVPGYPV YPNMSYPGHP
QQPRPPSNGA YPPHFVNQPD ARVRHPPQTP MGYGMPSPHP PPLINRFARP QVVFVSDDSH
VQFLKFPPAS HSHPQRPVIT HHQTAPAGHS AKSSR
//
