ID E6RCV2_CRYGW Unreviewed; 1085 AA.
AC E6RCV2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Membrane protein, putative {ECO:0000313|EMBL:ADV24624.1};
GN OrderedLocusNames=CGB_J1650W {ECO:0000313|EMBL:ADV24624.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24624.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV24624.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CP000295; ADV24624.1; -; Genomic_DNA.
DR RefSeq; XP_003196411.1; XM_003196363.1.
DR AlphaFoldDB; E6RCV2; -.
DR GeneID; 10184946; -.
DR KEGG; cgi:CGB_J1650W; -.
DR VEuPathDB; FungiDB:CGB_J1650W; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_3_0_1; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000007805; Chromosome J.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..237
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 259..485
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 496..776
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 13..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1085 AA; 121454 MW; DA5031F6A9197413 CRC64;
MASMAAWQSF FQNGDSDGGW PIFGEPDENG GNGTSPLPPG SGPTQKFNGP WFSTQLILSL
SIGIISFLVF CFLRTRWETV YMGRTKLKDF SPISAHDPDA HYTSGTNRFF GWILPTLRTS
EFTVLQTVGL DAAVLLNFYR MCLSLFGVSA LLALIVLIPL NLFRNGSTDS GPEQPGSNDT
LIWDGIPSFS SRQLFNTTSP HPRSNLYDLL LDPTTSSSIH LIFTYLFTFL SLSFFHKNFH
RFVLSRQAFG LQLIHSISAR TVLVTKLPTH LRGDRALAEY FEACNFTVES VNICRDVEPL
KRGLERRTLA LTKMEEAWAE WVGNPAKKGS GYDPHVYSGK STPQGQHESA SEGMLVDVDN
SETNDTTSLL STAPQTYGTA EDAEANFHPH SHIHIQTTRP RPTFRPRWFG TKVDAIEHWE
KKFKAADVEV KEMRRTGKFG ATHAAFVTFE DARDAQVACQ TVHYPHHSQA TTTLAPEPRD
VVWQHISMSI RESQIRDFIV MGIMVVLILT WIVPVSSLAT LLSYEEIKKI MPWLARLIDS
SPRLAAIVQN SLPSLALITF NGLLPFLLEW LSYMQAFKSR SAIEYSLMKK HVILISYHLF
LLISVLLIFL LTSTYWALVR DLVDTPMKIP EKLARALQGS NVRNFMVSYV MLQALGLMPL
QLLNLGPLFS LAFARAFWTK TPRDYAEANA PPMLNYGWVY PQALLVFTIT LVYSVMSPLI
LIFGAIYFAM AYLVFKYKLL FIYFKPYESN GEAWRITFAR TLWALIIFQL FMTGLFSLRT
YFWASGIMAP LIIYTLWRSW MMWRDFGPLS EYLAISSVCE VQRGEGVHGI LGVGGDAVSR
SQSMINHRRY AMNDETLYVA PSDSRTDYSQ PPMNNFYYSV LNTGRRRYAH PALDGSLPTP
WLPAIREDDG EDHKGRGTKA IVLSLRRKVV KRLRGHREDG DISGNGEASM EGSHESLAIP
EGWTHEESNT ARPSRTSLSH AQQESYPSSS LSANPWGDPS PVSSLPNTRS ASTLKKFSYK
AGRGPVALPE EGNVWGDDEP ESPSTYFHNR ERGSASSNIN QNVIGASEIG QGSSAPVQPG
VGGAL
//
