ID E6REL5_CRYGW Unreviewed; 757 AA.
AC E6REL5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN OrderedLocusNames=CGB_L0550C {ECO:0000313|EMBL:ADV25133.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV25133.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV25133.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP000297; ADV25133.1; -; Genomic_DNA.
DR RefSeq; XP_003196920.1; XM_003196872.1.
DR AlphaFoldDB; E6REL5; -.
DR GeneID; 10185454; -.
DR KEGG; cgi:CGB_L0550C; -.
DR VEuPathDB; FungiDB:CGB_L0550C; -.
DR eggNOG; ENOG502RFXZ; Eukaryota.
DR HOGENOM; CLU_007379_1_0_1; -.
DR OrthoDB; 1423507at2759; -.
DR Proteomes; UP000007805; Chromosome L.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46006:SF7; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 221..600
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 580..607
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83110 MW; F51D2106723DB47F CRC64;
MKSFFSRLKH SNESEKLNSS SRGKEKERLS ILKPRSSSIN AATPPLQLRE YIEEPPEEIL
SCDFENRLVD QFASKPLVAI GERRNPTPGG ERKVTFKSPP PTPADSVVLD SRVGSMSSPQ
EVLPKRIDSI HRPNPISRPG SSRQSFIHSF PRPSSSRKAS FPSSSFRGSS PTKRSLGVFS
PSPSEMSAAT GSTASFLPVA NTWSEMTDPD LVDNLGMQER TRQEVLWEIV SSEERYLNDL
LSIDEAFCKP LVHSSTSPRL EFYDPFHPLA HTRSATSPTS SCYTPSVGGS SINLPIASKF
ASTAQFISPS DSSTSSAAPL TPNEDLLGFG FGSATLLGAG LGFDSLNSGP ARLTASNTLN
NAESRPVKKS STVSLKRQSL PPLQRASSSA PSRASAVSRT SFHKLSKHPR NSSSDIPSRE
DVELPEDLAL VLKAINGGIL EGHLKLTAAL RRRYDDQYPL VRSLADIFIA HSYVLREYST
YVLHLEKALQ QVTQALSPSH PPPPISFPKP KRASFPSAHF SSARQPNALT AYLTHLESLA
LASGSPGLLI SLSKPFQRLI KYPLMFQNLL YHTDPSLKEY EKTVEMVEEI EGVVRALEDE
KIGEEEREET RDIWGRIAGL DGDKVLLFPK SSRLLIGETP LSEVSPSTAN LHLSTNLPNS
RDGTKPLLPK KSSRKLSDIL KGQGAGKDEL WVVRFTDMSL LCAKTGTTAL PLSISPKKSE
KKHGNGAGRK GGGRERNIYK FVRVWAWHID EEEDRKR
//
