ID E6S8V6_INTC7 Unreviewed; 739 AA.
AC E6S8V6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Drug exporter of the RND superfamily-like protein {ECO:0000313|EMBL:ADU48093.1};
GN OrderedLocusNames=Intca_1580 {ECO:0000313|EMBL:ADU48093.1};
OS Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC
OS 12989 / 7 KIP).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Intrasporangium.
OX NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU48093.1, ECO:0000313|Proteomes:UP000008914};
RN [1] {ECO:0000313|EMBL:ADU48093.1, ECO:0000313|Proteomes:UP000008914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC {ECO:0000313|Proteomes:UP000008914};
RX PubMed=21304734; DOI=10.4056/sigs.1263355;
RA Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S., Cheng J.F.,
RA Detter C., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Pukall R., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Intrasporangium calvum type strain (7 KIP).";
RL Stand. Genomic Sci. 3:294-303(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002343; ADU48093.1; -; Genomic_DNA.
DR RefSeq; WP_013492408.1; NC_014830.1.
DR AlphaFoldDB; E6S8V6; -.
DR STRING; 710696.Intca_1580; -.
DR KEGG; ica:Intca_1580; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_0_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000008914; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 573..716
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 739 AA; 77013 MW; 3DCB7A48212F2F55 CRC64;
MPAHPVPEPS RATRPAAPPT LLARLGRSTG RHPLWWVLAW VVAALVSFAV AVGGVTGESL
FDRLTSGEPR VPGQSQTARE VIQQVEPSLD TVMLQVDGAP LGDPRALEAA AVATGRITQL
AGVVRVRSPL LSPQGLDDPA VRPLLAGGSP DRGRFVTIVD LAGGRADSEL AATRTSVEAG
LATVVEALPG ATGSVGSYHH VIKAITGTIE SDLVRGEGIA LPLTFLVMVL VFGGFIAAGM
PISGAVVSIG GALLSLFAFS HALDLDATVV NIVTLLGLGL SIDYGLLTVS RFREELSVGP
GGTPTREQAV VAAERTVATA GRTVLFSGVT VAIALAGLLI FEAEIMRAIG LAGVSVVLVA
MVVAVTLVPA LAVLGSGRLS RRASRSVEDT GAFSRLAASV QRRPFVVIVG GLVALAALAS
PTLDMRLTAS GTELLPVSAP QRAFFDTLRS DYPALAAPEV TVVARTSDTA AVRTALEPFE
AAPGVTDLTV RPLGGEHQLA AFQVEGPPTS NEAQDLVTAL SQLRPGFETW VTGQASGQID
FLDSMARGAP WAIGLVVLGT FVLLFLMTGS VVIPLKALLL NVISLGAALG VVVWVFQHGN
LEGLLRFTSV GAVESMVPFL VLAFGFGLSM DYELFLLSRI VEEHEAGADN DRAVALGLQR
TGRIITSAAL LIIIVFAGFI AGDILIIKEM GTALVAAVLI DATIVRMLLV PATMTVLGRW
NWWAPGPLRR LHTRYGLRH
//
