ID   E6UVR9_VARPE            Unreviewed;       809 AA.
AC   E6UVR9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Aldehyde Dehydrogenase {ECO:0000313|EMBL:ADU35302.1};
GN   OrderedLocusNames=Varpa_1084 {ECO:0000313|EMBL:ADU35302.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU35302.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU35302.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU35302.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT   paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-e00813(2013).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036490, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP002417; ADU35302.1; -; Genomic_DNA.
DR   RefSeq; WP_013539547.1; NC_014931.1.
DR   AlphaFoldDB; E6UVR9; -.
DR   STRING; 595537.Varpa_1084; -.
DR   KEGG; vpe:Varpa_1084; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_018339_0_0_4; -.
DR   OrthoDB; 6187633at2; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:UniProtKB-UniRule.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR011408; Aldehyde_DH.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 2.
DR   PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR   SUPFAM; SSF53720; ALDH-like; 2.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          54..495
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          556..777
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        275
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   809 AA;  85492 MW;  902C5C2854EBB22D CRC64;
     MSSSQNHSNS SVARYFDTMD YGPAPESDTD ARQWLARHAE GFGHFIDGRF TAASAGAQFD
     TTEPATGQCL AGIAQGAAQD VDAAVAAARA AQPGWLALGG HGRARHLYAL ARMVQRHARL
     LAVVEALDNG KPIRETRDLD VPLVARHFYH HAGWAQLQER EFADQVPLGV VGQIIPWNFP
     LLMLAWKIAP ALALGNTVVL KPAELTPLSA LLFAELAAEA GLPPGVLNVV TGDGATGAAL
     VAHEGVDKIA FTGSTDVGRL IREATAGSGK SLTLELGGKS PFIVFDDADI DAAVEGVVDA
     IWFNQGQVCC AGSRLLLQEG IAADFIERLK RRMQSLRVGS PLDKAIDMGS LIDPTQLERV
     RTLVATGVRE GANCYQAPGA LPPGGSFFPP TLLTNVHPAS TVATEEIFGP VLVTMTFRTP
     DEAVALANNT RYGLAASVWS ETIGLALGVA PQLQAGVVWV NATNLFDAGV GFGGYRESGY
     GREGGREGCY EYLKPRAWAE RKPRTAAVAT NAANEASKTQ AKPSSVLPPI DRTAKLFVGG
     KQVRPDGELS HPVLAANGQR VGEVGTGNRK DIRNAVAAAR SAASWSSATP HRRAQALYYL
     AENLAARADE FAGRIASLTG VGAPAAESEV DASVSRLFAY GAWADKYEGT VHVPPLRGVA
     LATVEPIGVV GVVCPDEAPL LSFVSLFAPL MAMGNRTVIV PSEKHPLVAT DFYQVLETSD
     LPAGVINLVT GHAASLVQTL AEHDDVDALW VFGAKALSRN AERLSVGNLK RTLVDQGLAT
     NWHDAASAEG ALFLRHATQV KNIWIPYGE
//