ID   E6UWF7_VARPE            Unreviewed;       827 AA.
AC   E6UWF7;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family {ECO:0000313|EMBL:ADU39887.1};
DE            EC=1.1.5.2 {ECO:0000313|EMBL:ADU39887.1};
GN   OrderedLocusNames=Varpa_5735 {ECO:0000313|EMBL:ADU39887.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU39887.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU39887.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU39887.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT   paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-e00813(2013).
CC   -!- COFACTOR:
CC       Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC         Evidence={ECO:0000256|ARBA:ARBA00001931};
CC   -!- SIMILARITY: Belongs to the bacterial PQQ dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00008156}.
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DR   EMBL; CP002417; ADU39887.1; -; Genomic_DNA.
DR   RefSeq; WP_013544082.1; NC_014931.1.
DR   AlphaFoldDB; E6UWF7; -.
DR   STRING; 595537.Varpa_5735; -.
DR   KEGG; vpe:Varpa_5735; -.
DR   eggNOG; COG4993; Bacteria.
DR   HOGENOM; CLU_018478_1_0_4; -.
DR   OrthoDB; 9794322at2; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0008876; F:quinoprotein glucose dehydrogenase activity; IEA:UniProtKB-EC.
DR   CDD; cd10280; PQQ_mGDH; 1.
DR   Gene3D; 2.140.10.10; Quinoprotein alcohol dehydrogenase-like superfamily; 2.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR017511; PQQ_mDH.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   NCBIfam; TIGR03074; PQQ_membr_DH; 1.
DR   PANTHER; PTHR32303; QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C); 1.
DR   PANTHER; PTHR32303:SF4; QUINOPROTEIN GLUCOSE DEHYDROGENASE; 1.
DR   Pfam; PF13360; PQQ_2; 1.
DR   SMART; SM00564; PQQ; 5.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADU39887.1}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          545..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  87733 MW;  4097139107B64086 CRC64;
     MTRSSAQFTQ PAESSSPSAL LVVVAVLIGL AGLVLLVAGA WLIALGGSWY YLVAGLGLIA
     SALLLRRGGG IGLMFYAAVV LLTLVWALWE VGFDWWPLAA RGDVFFVVGL FLLSPWVARA
     LARRDATGIG RTRAVLGVVL AAFLVAAVFS WTREPGRIEG IAPLPDASNA SNASSSATAA
     AALASPPPPK DDWTAYGGTG FGQRYSALDQ ITPANVGQLE EAWHFRTGDV RGQPGDPEET
     TFEVTPLKIG ERLFLCTPHQ AVIALNATTG EQIWRYTPDI QKSLALQHLT CRGLSYYAGS
     TAQGATPTPS PSPSPSAPAG ECDAKLFMPT ADGRVIALSP ESGKPCMAFG GGSGQIDLWK
     NMPNVKAGSY YSTSPVVVTR SLIVVGGTVL DNVSTKETSG VIRAFDVNTG ALVWNWDSGN
     PDETAPIAAD RTYTVNSPNS WSISSVDEAL GLVYVPTGNQ PPDQWGGKRT EGAERYSSSV
     VALDLATGRV RWSFQTVHHD LWDYDVPSQP SLIDLRVGSE TIPALVQPTK QGELFVLDRR
     NGRPIVPVNE RPAPQGAATG DRTAPTQPVS GLSFDPPALK PSDMWGGTIF DQLACRIAFH
     RLRYEGRFTP PSTQGSLIYP GNFGVFNWGS IAVDPQRQIA FTTPASLAFV SQLVPRADDT
     TLYVQGKSRP NDSLPALNEN FGAPFAIKLS AFTSVLGLPC QAPPWGHVAG ADLRSGKVIW
     MHKNGTVRDS SPLPLPFAMG VPNLGGPVMT AGGVAFLSGT LDQYVRGYDV GNGKELWRSR
     LPAGGQATPM TYRGSDGRQF VLVAAGGHGS LGTRTGDHVI AYALPKR
//