ID E6XDE4_CELAD Unreviewed; 636 AA.
AC E6XDE4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000256|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000256|HAMAP-Rule:MF_00221};
GN OrderedLocusNames=Celal_1775 {ECO:0000313|EMBL:ADV49076.1};
OS Cellulophaga algicola (strain DSM 14237 / IC166 / ACAM 630).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Cellulophaga.
OX NCBI_TaxID=688270 {ECO:0000313|EMBL:ADV49076.1, ECO:0000313|Proteomes:UP000008634};
RN [1] {ECO:0000313|EMBL:ADV49076.1, ECO:0000313|Proteomes:UP000008634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14237 / IC166 / ACAM 630
RC {ECO:0000313|Proteomes:UP000008634};
RX PubMed=21475589; DOI=10.4056/sigs.1543845;
RA Abt B., Lu M., Misra M., Han C., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Mavromatis K., Ovchinikova G., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Brambilla E., Rohde M., Tindall B.J., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Cellulophaga algicola type strain (IC166).";
RL Stand. Genomic Sci. 4:72-80(2010).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000256|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_00221}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_00221}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000256|HAMAP-
CC Rule:MF_00221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00221}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002453; ADV49076.1; -; Genomic_DNA.
DR AlphaFoldDB; E6XDE4; -.
DR STRING; 688270.Celal_1775; -.
DR KEGG; cao:Celal_1775; -.
DR eggNOG; COG0589; Bacteria.
DR eggNOG; COG1914; Bacteria.
DR HOGENOM; CLU_020088_2_0_10; -.
DR Proteomes; UP000008634; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd00293; USP_Like; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006016; UspA.
DR NCBIfam; TIGR01197; nramp; 1.
DR NCBIfam; NF037982; Nramp_1; 1.
DR PANTHER; PTHR11706:SF101; MANGANESE TRANSPORTER SMF1; 1.
DR PANTHER; PTHR11706; SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER; 1.
DR Pfam; PF01566; Nramp; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00221};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00221};
KW Ion transport {ECO:0000256|HAMAP-Rule:MF_00221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00221};
KW Symport {ECO:0000256|HAMAP-Rule:MF_00221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00221}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 71..94
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 114..141
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 147..165
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 254..281
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 309..332
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT DOMAIN 502..635
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 636 AA; 70356 MW; 38B1EBE2C3A7ED30 CRC64;
MRQRYTMEEE IKHNKRSLEE VNESVSIAQN TTVWKKIAAF FGPAYLISVG YMDPGNWATD
LAGGSQFGYQ LLWVLLMSNI MALLLQSLSA RLGIVQGKDL AQASRETYSK PINFILYILA
EIAIAACDLA EVIGMAIGLQ LLFDIPLTWG VCITVLDTFL LLFLINKGIR KMEAFIISLI
AIIGISFFVE MLFAKPDVGE MIIGLVPTLP NSAALYIAIG IIGATVMPHN LYLHSSLVQT
RKFDKTKKGI KQAIKYNFID ATIALNLAFF VNAGILILAA ATFYKNGMFE VAEIQDAHKL
LEPLLGSKWA GILFALALIA AGQSSTITGT LAGQIVMEGY LNLRIQPWVR RIVTRIIAIV
PALFTVIYYG ERATGELLIL SQVVLSLQLG FAIIPLIHFV SDKEKMGDFA IGTLTKIASW
VVALVIVILN AKLVYDEIAG WLVSSSNPIY IWVFVVPIAV GAVVLLIYII IKPILNRVPR
HVQHVPHIEE IFINENIKKI NYDKIAIAID FSSMDEKSIR TALHLGGKEA TYTLIHVVET
AGSLVHGSNA YDYETLSDRS YLEKYQEKLV KMGYTIQISL AFGNPKKGIA KIVNQENFDL
LIMGAHGHKL WKDILLGTTV DAVRHKVAIP VLIVKE
//
