ID E6XRX6_SHEP2 Unreviewed; 389 AA.
AC E6XRX6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN OrderedLocusNames=Sput200_1416 {ECO:0000313|EMBL:ADV53881.1};
OS Shewanella putrefaciens (strain 200).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=399804 {ECO:0000313|EMBL:ADV53881.1, ECO:0000313|Proteomes:UP000008209};
RN [1] {ECO:0000313|EMBL:ADV53881.1, ECO:0000313|Proteomes:UP000008209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=200 {ECO:0000313|EMBL:ADV53881.1,
RC ECO:0000313|Proteomes:UP000008209};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Kolker E., Lawrence C., McCue L.A., DiChristina T., Nealson K.,
RA Fredrickson J.K., Woyke T.;
RT "Complete sequence of Shewanella putrefaciens 200.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP002457; ADV53881.1; -; Genomic_DNA.
DR AlphaFoldDB; E6XRX6; -.
DR KEGG; shp:Sput200_1416; -.
DR PATRIC; fig|399804.5.peg.1452; -.
DR HOGENOM; CLU_009834_22_1_6; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000008209; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:ADV53881.1}.
FT DOMAIN 36..374
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 389 AA; 42641 MW; 3E4AE7E50561A4EC CRC64;
MTNVVDNDVV EHVANQVSTT QNVVFQTLAT ASGKLVGVVT LNVEKALNAL DLDMVRAMTA
QLNLWKKDPL IACIVLDGSG EKAFCAGGDV RALYHASIAA KGQVTEEAKV FFEEEYRLDY
LLHTFGKPVL VWGDGIVMGG GLGLMAGASH RVVTETSRIA MPEVTIGLYP DVGGSYFLNR
MQGKMGLFLG LTAYQLNAAD ACYVGLADHY LNRDDKELMF DAMATLDWSD TPALNHQRLD
SMINELSNQV DIPKGESVLA ESQEIIDRLM AGSLQDIAAR MSTLISEEKW LIKARDTFLA
GSPISWHLVY IQAQLGSKLS LAQCFKWELT TSVNVCAHGD FCEGVRALLI DKDKKPQWRF
KDVNSVPTAV LEQILASPWG EAHPFNQLS
//
