ID E6Y5N8_KRYMA Unreviewed; 416 AA.
AC E6Y5N8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Wilms tumor protein homolog {ECO:0000313|Ensembl:ENSKMAP00000010158.1};
DE SubName: Full=Wilms' tumor suppressor 1 {ECO:0000313|EMBL:ACL00868.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|EMBL:ACL00868.1};
RN [1] {ECO:0000313|EMBL:ACL00868.1}
RP NUCLEOTIDE SEQUENCE.
RA Paulin L.G.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACL00868.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21632026; DOI=10.1016/j.aquatox.2011.04.020;
RA Rhee J.S., Kim B.M., Lee C.J., Yoon Y.D., Lee Y.M., Lee J.S.;
RT "Bisphenol A modulates expression of sex differentiation genes in the self-
RT fertilizing fish, Kryptolebias marmoratus.";
RL Aquat. Toxicol. 104:218-229(2011).
RN [3] {ECO:0000313|Ensembl:ENSKMAP00000010158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EU867511; ACL00868.1; -; mRNA.
DR RefSeq; NP_001316285.1; NM_001329356.1.
DR Ensembl; ENSKMAT00000010320.1; ENSKMAP00000010158.1; ENSKMAG00000007444.1.
DR GeneID; 108246890; -.
DR KEGG; kmr:108246890; -.
DR CTD; 30245; -.
DR GeneTree; ENSGT00940000156734; -.
DR OMA; GQSNHTT; -.
DR OrthoDB; 5359277at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000976; Wilms_tumour_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF71; KRUEPPEL-LIKE FACTOR 16; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF02165; WT1; 2.
DR Pfam; PF00096; zf-C2H2; 3.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 290..319
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 320..349
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 350..377
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 381..410
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 45693 MW; 5E9E986061D0798A CRC64;
MGSEVRDLNS LLPPVPAGPS PLPVTTAPQW APVLDFHSAA AAASPYPSLA APHTSLGAHS
FIKQEPSWGA AGDPHHHEAD PHCGLSAFTV HFSGQFTGTG ACRYGAAFGA PPPPAPAAPS
QPPPVAGPHH HQTPGRMFSS PSYLSSCMDT QPAPRNQTGY GAVAFEGAGN YGHTPTHHSS
QFSGHSFKHE DALTQQNAMG EQQYPVPPPV YGCHTPSDGC PSSQALLLRN PYNSHPAGYD
SDPSAPMVYS CSTQYRIHTH GVFRGIQDVR RVPGIAPAIV RSEGSEKRPF MCAYPGCNKR
YFKLSHLQMH GRKHTGEKPY QCEFTDCGRR FSRSDQLKRH QRRHTGVRPF ECETCQRKFS
RSDHLKTHTR THTGKTSEKP FSCRWPNCQK KFARSDELVR HHNMHQRNLS KLQLSI
//
