ID E6YZV8_BARSR Unreviewed; 464 AA.
AC E6YZV8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Probable periplasmic serine endoprotease DegP-like {ECO:0000256|ARBA:ARBA00013958};
DE EC=3.4.21.107 {ECO:0000256|ARBA:ARBA00013035};
DE AltName: Full=Protease Do {ECO:0000256|ARBA:ARBA00032850};
GN Name=htrA {ECO:0000313|EMBL:CBI82396.1};
GN ORFNames=B11C_40251 {ECO:0000313|EMBL:CBI82396.1}, BscR1v2_009270
GN {ECO:0000313|EMBL:AQX30859.1};
OS Bartonella schoenbuchensis (strain DSM 13525 / NCTC 13165 / R1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=687861 {ECO:0000313|EMBL:CBI82396.1};
RN [1] {ECO:0000313|EMBL:CBI82396.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R1 {ECO:0000313|EMBL:CBI82396.1};
RX PubMed=21347280; DOI=10.1371/journal.pgen.1001296;
RA Engel P., Salzburger W., Liesch M., Chang C.C., Maruyama S., Lanz C.,
RA Calteau A., Lajus A., Medigue C., Schuster S.C., Dehio C.;
RT "Parallel evolution of a type IV secretion system in radiating lineages of
RT the host-restricted bacterial pathogen Bartonella.";
RL PLoS Genet. 7:E1001296-E1001296(2011).
RN [2] {ECO:0000313|Proteomes:UP000190811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 {ECO:0000313|Proteomes:UP000190811};
RX PubMed=28338931; DOI=10.1093/gbe/evx042;
RA Harms A., Segers F.H., Quebatte M., Mistl C., Manfredi P., Korner J.,
RA Chomel B.B., Kosoy M., Maruyama S., Engel P., Dehio C.;
RT "Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent
RT Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.";
RL Genome Biol. Evol. 9:761-776(2017).
RN [3] {ECO:0000313|EMBL:AQX30859.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 {ECO:0000313|EMBL:AQX30859.1};
RA Harms A., Segers F.H.I.D., Quebatte M., Mistl C., Manfredi P., Koerner J.,
RA Chomel B., Kosoy M., Maruyama S., Engel P., Dehio C.;
RT "Evolutionary dynamics of pathoadaptation revealed by three independent
RT acquisitions of the VirB/D4 type IV secretion system in Bartonella.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Acts on substrates that are at least partially unfolded. The
CC cleavage site P1 residue is normally between a pair of hydrophobic
CC residues, such as Val-|-Val.; EC=3.4.21.107;
CC Evidence={ECO:0000256|ARBA:ARBA00001772};
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DR EMBL; CP019789; AQX30859.1; -; Genomic_DNA.
DR EMBL; FN645509; CBI82396.1; -; Genomic_DNA.
DR AlphaFoldDB; E6YZV8; -.
DR STRING; 687861.BscR1v2_009270; -.
DR MEROPS; S01.442; -.
DR Proteomes; UP000190811; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 2.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.42.60; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011782; Pept_S1C_Do.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR NCBIfam; TIGR02037; degP_htrA_DO; 1.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF129; SERINE PROTEASE HTRA2, MITOCHONDRIAL; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBI82396.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:CBI82396.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..464
FT /note="Probable periplasmic serine endoprotease DegP-like"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010595935"
FT DOMAIN 249..322
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT ACT_SITE 105
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 135
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 211
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
SQ SEQUENCE 464 AA; 50603 MW; 60A4630DFBAC50A0 CRC64;
MKRSILIGLF FVIMTLISFH STNAQVPSTQ SKTTFSFAPL VKKTVPSVVN IYAARQVKVR
SPFEDDPFFE QFFGRYQDNR PLRTQSSLGS GVIVDVRGLV VTSYHIIKGA YEIKVVLSDG
REFESAVILK DEATDIAILE INSKDTQFPV LPLGNSDAVE VGDLVLAIGN PFGVGQTVTS
GIVSAQARRR VGISEFDFFI QTDAAINPGN SGGALIDVNG RLIGINTAIY SRSGGSTGIG
FAIPANLIKV VLDTVKRGEK FFVPPYIGAS FQRVTPDVAG GLGLERPYGA LVIEIVQDSP
AAKAGLKVGD VILSVQDVQI DSPDDLIYRL ITTSVGQNLN LEYLRDGKTL KTKITVSSMS
NSSFVKSEKI IDKSPLSGAE VLDLTPQNSQ RFHLPATVKG VVIANLDNMS NAAEIFRSGD
ILRAVNGHQI QTVNQLKKIL MQEHPRIWQL EYERNGVYIR QFIR
//
