ID E6ZI68_DICLA Unreviewed; 1450 AA.
AC E6ZI68;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN Name=POL {ECO:0000313|EMBL:CBN81752.1};
GN ORFNames=DLA_XVIII00100 {ECO:0000313|EMBL:CBN81752.1};
OS Dicentrarchus labrax (European seabass) (Morone labrax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Moronidae; Dicentrarchus.
OX NCBI_TaxID=13489 {ECO:0000313|EMBL:CBN81752.1};
RN [1] {ECO:0000313|EMBL:CBN81752.1}
RP NUCLEOTIDE SEQUENCE.
RA Kuhl H., Tine M., Hecht J., Knaust F., Reinhardt R.;
RT "Analysis of single nucleotide polymorphisms in three chromosomes of
RT European sea bass Dicentrarchus labrax.";
RL Comp. Biochem. Physiol. Part D Genomics Proteomics 6:70-75(2011).
RN [2] {ECO:0000313|EMBL:CBN81752.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.ygeno.2011.06.004;
RA Kuhl H., Tine M., Beck A., Timmermann B., Kodira C., Reinhardt R.;
RT "Directed sequencing and annotation of three Dicentrarchus labrax L.
RT chromosomes by applying Sanger- and pyrosequencing technologies on pooled
RT DNA of comparatively mapped BAC clones.";
RL Genomics 0:0-0(2011).
RN [3] {ECO:0000313|EMBL:CBN81752.1}
RP NUCLEOTIDE SEQUENCE.
RA Tine M., Kuhl H., Beck A., Bargelloni L., Reinhardt R.;
RT "Comparative analysis of intronless genes in teleost fish genomes: Insights
RT into their evolution and molecular function.";
RL Mar. Genomics 4:109-119(2011).
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; FQ310508; CBN81752.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF08284; RVP_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 455..634
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 973..1132
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1274..1324
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 1388..1446
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 48..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..89
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 162149 MW; 2121B25AE4999AFF CRC64;
MDPADPDSVR SALAYQGQRV GQHEKVLDEI VAAIQDLRCS VAALGSKLDQ VSTPPTAPTT
ATEAATPSAS PAMPHAASPP PPPREPHVPT PERYAGDLGA CGRFLLQCSL VFQQQPLTYS
SDSAQVAFVI SLLSGKAAQW ATALWEKHSP ICDSFQRFSE ELRKVFDHPV QGKEAAKRLL
NLRQGSGSVA EFSVEFRILA AESGWDEEAL QTVFVHGLSE VMKDELAARD SAASLDELIS
LAIRLDNRLR ERQRERRGRP QASPFPALPR ATISVGPQLA APSKHPSSQI PPEPVEEPMQ
LGRTRLTQAE RQRRISPPYS HAIKCVPSLA VNSIPLTALV DSGAEESFID SAFVLQARIP
TVKLPDNQPV NALDGKHLAN ITRQTVPLTL ILSGNHQYHD LGEVFSKHRA VTLPPHRPYD
CAIELLPGST LPTSRLYNLS RPEREAMEKY IGDSLAAGLI RPSSSPVGAG FFFVTKKDQT
LRPCIDYRGL NDITIKNKYP LPLIDPAFEP LHKAQVFSKL DLRNAYHLVR IREGDEWKTA
FNTPLGHFEY LVMPFGLTNA PAVFQALVND VLRDMLNRFL FVYLDDILIF SQSQEEHVQH
VRQVLQRLLE NKLFVKAEKC EFHVTSVSFL GFIIERGQVK ADPAKIQAVA DWPSPTTRKQ
LQRFLGFANF YRRFIRNYSK VAAPLTKLTS VKVPFAWSPE AENAFLALKE LFTSAPVLHH
PDPSLQFVVE VDASDTGVGA VLSQRSPKDQ KLHPCAFLSR RLSPAERNYD VGNRELLAVV
VALQEWRHWL EGAALPFIVW TDHKNLAYLR SAKRLNSRQA RWALFLDRFV FTLTYRPGSR
NAKPDALSRQ ADPETQETEP ETILPASCVV PAVNWRIEAL VKQAQRSQPD PGNGPPNRLF
VPDSARSQVL QWAHASKISC HPGYQRTLDF LRRKFWWPSM ARDTRAFVAA CSVCARGKSS
HQPPAGLLHP LPVPRRPWSH IAVDFVTGLP TSEGNDTILT IVDRFSKSVH FVPLPKLPSS
LETAKLLVTH VFRLHGIPQD IVSDRGPQFA SQVWRAFCQA LGASVSLSSG YHPQSNGQTE
RANQQLEAAL RCVAARHPVS WCSFLPWIEY AHNSLTCAAT GMSPFMAAYG FQPPLFPSQE
GEVAVPSVQD HLRRCRRIWT EARAALLRTA ARNQRLADRH RLPAPDYTPG QKVWLSSRDL
PLQVESRKLA PRFIGPFEVD RIINPVAVRL KLPPSLHVHP VFHVSLLKPV SSSPLCPPAD
PPPPPRLIDD HPAYTVRQIL DVRRRGRGFQ YLVDWEGYGP EERSWVPRHF ILDSSLLSDF
YRSHPDKPGS LCAVWLPVSA HLCLCVSGLF RHLTHPFLLW PPLIPPAPLC PPADPPPPPR
LIDDHPAYTV RQILDVRRRG RGFQYLVDWE GYGPEERSWV PRHFILDSSL LSDFYRSHPD
KPGRPPGGVL
//
