ID E6ZRH7_SPORE Unreviewed; 5424 AA.
AC E6ZRH7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=sr15752 {ECO:0000313|EMBL:CBQ69834.1};
OS Sporisorium reilianum (strain SRZ2) (Maize head smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Sporisorium.
OX NCBI_TaxID=999809 {ECO:0000313|EMBL:CBQ69834.1, ECO:0000313|Proteomes:UP000008867};
RN [1] {ECO:0000313|EMBL:CBQ69834.1, ECO:0000313|Proteomes:UP000008867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRZ2 {ECO:0000313|Proteomes:UP000008867};
RX PubMed=21148393; DOI=10.1126/science.1195330;
RA Schirawski J., Mannhaupt G., Muench K., Brefort T., Schipper K.,
RA Doehlemann G., Di Stasio M., Roessel N., Mendoza-Mendoza A., Pester D.,
RA Mueller O., Winterberg B., Meyer E., Ghareeb H., Wollenberg T.,
RA Muensterkoetter M., Wong P., Walter M., Stukenbrock E., Gueldener U.,
RA Kahmann R.;
RT "Pathogenicity determinants in smut fungi revealed by genome comparison.";
RL Science 330:1546-1548(2010).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; FQ311438; CBQ69834.1; -; Genomic_DNA.
DR EnsemblFungi; CBQ69834; CBQ69834; sr15752.
DR VEuPathDB; FungiDB:sr15752; -.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000008867; Chromosome 17.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340}.
FT DOMAIN 5191..5339
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 862..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4429..5052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4465..4487
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4488..4505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4506..4539
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4565..4629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4630..4662
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4678..4712
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4713..4754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4755..4787
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4788..4802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4825..4840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4904..4962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4973..5031
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5424 AA; 594372 MW; 4922F62F639C4DF4 CRC64;
MGLVSTAAPA QGDASTSTRR SALDLDVYTS CISLKSELSE HVEAVSVLDE AIAALDAGSS
ASAALDRVGH LLLVPTCTLS VASQFKPVLL DLLVRSLKQA HDSGNADAQV LVKTLHTFAL
LISVFPAEIY DLSTRFVGTP AFSSLPQTLS TAAVEVRNQF LLDLYRLAAA APNTFAGHVG
ESCAQWAHRI VFSSQPSEPL ATRLLALRFF ALQQRISEKG RLELQQKCLD SLFIGAPDPY
TLDAVASLAF ETAGINLWTL ETEEFSRIQQ ARSSVASRQI AFLPRRSDTD IVTDKQQAQL
SPDDLSPEVC SIGGVLLARS SQIISRDDTI PLEDRFVETT GISPSLSQLA LRLSANYPIL
ISGPPSSGKS SLIRHLSQLL KGAETASTSS HLTIQLGDQS GIDAKQLLGS FVSSPTEPGK
FEWTEGALTR AVRQGKWVVL EDIDKAGSEV LSTVAQLVEQ LGPTKALGAR TTIDLGTRGK
VAAGDGFALF ATRSVASSSR HASSPSTATF LGSSHWSEVH IDSPSQNDVG SILANQFPRL
TSQQSHFVER LVATWYKLQR ATQPSAASSP ASAKAVGASA GSVRTATLRD LIKWCRRVQR
LLSAEPSMLS DPLSNPVQQE EIFIEACDIF LGSVPQAQDA SAAAAPASAH TSKAANGKST
DRYSALVELL AEELGLTSER AWWALKQRIP ELSVRSTEIS LNTDAGSSLI RVGRCELQRR
SKATAKRAAP VSRKFAMTKP SLLLLERLTV ATALAEPVLL VGETGTGKTT VVQHLASLLG
QPMVALNLSQ QTESGDLLGA FKPLDPKVPA TELHDQWTSL FARTFSSRRN ARFVEAERKA
FIAGKWSRLA LLWRESAKMA SQRKKGASKS EAAESANGDI TTAEADGRPG SGSRKKRKTE
RGAAEGSPAD VDDARADAEL DREWLELDAK ARDFGVQHGS KKKNLVFSFV EGPLVKALRQ
GDWILLDEIN LAAAETLDSL TGLLQSPTSS ITLTERGDLE PIPRHPNFRL FACMNPATDV
GKKDLPASLR SRFTELYVPS PDADREALTA IVEKYIGEHA LGDRGAIMDV AECYAEIRRL
AQQHQLADGA NQRPHFSIRT LSRALTFATD IAPQYGLRRS LWEGFIMAFT LLLDDASARV
VRAIIERHTL TKAKNARAIA TFVPPPPKGA EDGDFVQVGP FWLPTGPAPL DAAEDYILTP
SVQSKLVGLS RAALTRRFPV LIQGPTSAGK TSAVEYLARR TGHRFVRINN HEHTDIQEYI
GSYASDPDSG KLSFQEGLLV KALRKGDWIV LDELNLAPTD VLEALNRLLD DNRELVIPET
GEVVKPHPHF MLFATQNPPG LYAGRKVLSR AFRNRFLELH FDDVPRAELE TILTNRCKIA
PSYASRIVGV FEELQKRRQA GRVFETKQAF VTLRDLFRWG NREAVGYQQL AENGYMLIAE
RARRADDKET VKDVIEKIMR VKLDVDRMYL LEGPESEATL ARIGKALGGA IVNNLSNTSI
VRTSAFQRLL CLVATSLRYN EPVLLVGETG AGKTSVCEVL ATAFGRELHC VNCHQNTDTA
DLLGGQRPLR NRAAQQSAAK VACIGALDAL QITHALTAES KLEDVAACIE AVLSKEPEQL
AALEEAQKDV ARQTLRNALR SIYQATALFE WQDGPLVQAM RAGDHILLDE ISLADDSVLE
RLNSVLEPAR TLVLAERATS SSQLNSEADL SASQITGADG FQVLATMNPG GDYGKKELSP
ALRNRFTEIW VPHVDIRSDL IQIINAQWKD ARLSLWTEPI IDFSDWFIHQ IGGRDQSGLG
LRDLLTWASF MNELAVNASL DPALAFAHGA SLTIIDGLGA LPATAAMTAA GLDQLRDRCL
AKVAELIAPQ EYDPKLASLF EVDVSSERLR IGPFAISRGS LDLPSQGTGS FSFGAKTSAS
NAMRVLRALS VPGRSVLLEG SPGAGKTSLI TALAAAAGRP LTRINLSDQT ELVDLFGSDM
PLEGGGPGEF AWRDAAFLTA MQQGEWVLLD EMNLASQTVL EGLNSCLDHR GTVYVPELGR
SFTKHPNFRI FAAQNPHHQG GGRKGLPKSF LNRFIKVHIE ELTGDDILAI SSHLYPNFDI
EQLRKMIQFN FALHHQVVVK HSFGRIGAPW EFNLRDLMRW LDLLHTDLGL NKLGDPIEHL
ASLYIQRFRT ASDRQAAREL FRKSFGGDSA SDSRIVPTLT PSQARIGHAV LQRKPALSAV
HHQLVLLQSQ LPVLEALMDC VHKEWLAILV GPTGSGKTSV VRLLAQLAGA RLEEFQMNSG
TDTMDLIGTF EQYDPLGRSR HVLSTLLLEM QRCSETVAAS SNEHFAALLA ARNVVHAATG
SSAGTLAPES LSRAIEDVRL ATSRIDDDAL KRALEDASAV AVELAQSSSD TQRTTGKFEW
IDGPLLRALQ EGHWLMLDNA NLCSASVLDR LNSLFEVNGS LVISERGVVD GKVPVVRPHP
NFRVFMCLDP RHGELSRAMR NRGIEIVLLP QQGTASSDLE RLVQLCGADS VLSANSATSA
QRALMDASLH AQLVQRGLED RDVLDADTSL TARHRDAAIW TASQLMLTNA SLASAALPLF
LAGVQGSGSE AEASLLIRRS SPSSLKLTWQ VMTRCLSSVP MEVSALLQEV VSTTGLLQDS
RQALQLGLID SKRISRELCD YLLVDLRYED NVCRLLDSQS PPSQAVHLLL AALLHRLAAH
QIREAASTKR MQDLSILERS ARLSSTAMVH DEDQATTAVR NVFPLIVAVH RMVLAAMQSD
RTADLSAVTL RQVALLLRSG EYLQTLCTST ELDFSSIQIL VRFMSDLLRE ITGGGVDGDA
NLVQTIDLLG GSLQLTSGKA LFPIWSLFGA DEGMQTNLYR LICDEVTLLP PAVGGDLLKN
ALDVAATLCV AGKQSAAPAE LRDMMQLGWQ TLKMIRSASN KAAIQSQVQA LARSSATEKA
EAELLTLAEV SIKTPDCLQS GSQAFRMKLI MQLLESHSSP FMQAAAAPCR SALWALDSAS
AQSNALLSDF SWIRRLWPSE AGQASTSDGP AHLLRPSSLQ TLLESRFGTR SLFEKSLHDA
SVGRMIKSVG AALPASSPSR QEKLSSILVR FITLVSETLY NAALKDLAEH NLPAWKRVQG
LSECRTLLKT LLEAGQERLA EGTASALLEW VTVLENELEP ALSPSNGVDD ATLLGRAWIS
VALVMLRLYL PNVALDPIVA RRTMADFGDF CRAQLETELD LEVYAESIVT GEKSNRVIHD
LRAQIEETRM SLKTQAGDRA QAWRKPNLKL LSQFYRETSS FLREVVTAER VADLVQALIS
GPSEQAEQRE ASLQASVLSF GDRLRKTFAE LRDMVEPIIA SLLQLQLGLR LVRQAARIAS
APVDVKQRGA IVEALVSFPT AHSSTLLRQV DLSSQLQARS DVSASLIIVS TASVAYDHAS
LGIEVLESPD TLRNISRSYE RIFQLWALDR ERAKREEEEA SSLYKSRKIE ESIELDAEAE
EKEFRALFPE YDDDVLDGPR PAAAANGQEQ AKHKGMLLPP PRFVAVLNAH MAIFGQASMR
KGAADAFHAE RDSLVTKLMR KHHEDWSEAI DRAGAAFGLS SAIDDQLASS QTTKDFNFYL
DARPAEVRKA TAIVEELRTR LNVLIQEWPE QMVLQHIRDR CDAVLRLDAA SPVAKMLSAL
EQLLTHTEDW EGFASQQTSI QANRERISAQ IIEWRRLELS CWAELLNTQA RTFQDELGEW
WFRVYEILIR GTRAASADGP AAFKEHVEQL IDAVDQFVRS SPLGQFEARL SLLESYARFI
ERLVRLAPPK ESRGLKEVGM VLQNVTTFFR QFDERISGTL QSQRTVLEKD ITGFIKLASW
KDINIHALKQ SAQKTHRQLH KTLRKFRDIL RQPVDPMLAS HLDALTRREI PALSVDSLSH
RKMLDVSDKP SEAWTRAVSF ATLNESAPEH IRNMSKTLSV LQKMAGDRLW PALLRPTSAA
AGIADLADEI VDRQQQLAKL TPAFSKEDNE KAIKNLTARK RKAWSDLLKE LRRIGLSSFA
RTDMAAMNQS VMHIYTRPAL LAACPASLSD EPFSTLERLF FRLLAALPKV RDSLQSHSAD
LSTAELQRGV NYIEHVTHLV LQERDRMHSE LQSLSMLEKL NARMHDLHSA GLATVTRASR
SAPFQAVADF IARLADALNE IKAQAPTFLA TSAFPAPAAD TFLGRIPSLA AELMQRASSI
EALAKTAFAH DVDGGLFFLT EQERLGVESS RKLVEDVQRD LHDHVQSLPA LESLLYPVAQ
WTGEALPLFD RCLVTLEAPL KGKCKPEELV QQANTVVSAV LQVAQDIRRA GSAVSADPVA
TSEDAADSLP EKIISTELQA LQSQQANLRS ASVLSEVEKL SRLAQQLSRD TESEEMVQVQ
LAGVYPFLHE YAELLRAHLL ASAHFSRSLL KLDHTLCHLL TALASKGFCK PPEEQQDDGG
EGEDGEQLEG GTGLGDGSGA KDITDQMEDD DEIEELQKDE PADEGEEGDK TEREKNAKEA
DQDFGGDLED ISVDGDDDAG SDQDGDEGDE QEPEDAVGDV DPLDPNAVDE KVWDGNDDDE
DDKKDAPEDK TNKDLGADNA DGKEAESVPK ADDSGSADDK QKQERPAEGS RDEQQQQQDD
SKQDQADADQ QEGADEQDAA EPEDREGEDR EGAEEEENED ADVQGEGGGR QLDQEADQGE
NLDLDDDFNM DGGDGENDGD RDHDDDGLDE LSDMDQMPDH QRDDKRDDKA MDDLADDQPE
ANAEEQKQNE ETTEGEAAEQ EPEDDIKVDK DEGEDAMDED GEDEDAEAQS QQQQQRPAND
NAAGGDQDQV DPFDIDAVDQ GADNGGQDES ATQQQSSRSQ RGRRVDARND QSQAEQGMDL
DDSADAAPQE QADQPPSAGE RGARAPQAER DEASGDAEQD GEAEADPNPL RRMGDALEQF
RRRMQEIQSA RDDEEEQVAG EKAEHDGEGP PEDGDVEHVA NDDAAELQAL GAAKEQDEVR
KLGDMGIEDE DESLGAKPRG QDVNEQEEHE QREPQPLPDQ PVKEERNEVS DGQQKAFMPS
DLKPPSSSLT AEQEALLDED GDANMADDVQ VKQEEDDDEA MTPLPDDVRQ EADDEVQQQL
EAFRNVVSSE ERLAKAGDLW RSYASLTADL AFSLCEQLRL ILAPTLATRL NGDFRTGKRL
NMRKIVPFIA SDFAKDKIWL RRTKPSSREY QVMLAIDDSR SMSESRSAHL AYQTLALVTG
ALSRLEVGDV SICRFGEDVD SLHDFGRGSF SDQNGAHVID RLGFQQKKTN VLRLVERSLE
TLAEARASRS SSSASQGGEL WQLEIIISDG ICQDHARLRS LLRRAAEQRV MLVFVVIDSL
QQPAPAAAGS AAQQQQQQQR SSILDMTNAS YHTDASGRLQ LKMERYMDTF PFDYYVVVRE
VEALPEVLSA TLRQWVEKIR ETES
//