ID E7BBS3_DROME Unreviewed; 134 AA.
AC E7BBS3;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=GEO07579p1 {ECO:0000313|EMBL:ANY27240.1};
DE SubName: Full=Insulin-like peptide 4 {ECO:0000313|EMBL:CBY85561.1};
GN Name=dilp4 {ECO:0000313|EMBL:CBY85561.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CBY85561.1};
RN [1] {ECO:0000313|EMBL:CBY85561.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNIII_1 {ECO:0000313|EMBL:CBY85561.1};
RA Guirao-Rico S.;
RT "Evolucion molecular de genes implicados en la via de la insulina en
RT Drosophila: genes dilp1-7 e InR.";
RL Thesis (2010), Department of Departament de Genetica, Universitat de
RL Barcelona, Barcelona, Spain.
RN [2] {ECO:0000313|EMBL:CBY85561.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNIII_1 {ECO:0000313|EMBL:CBY85561.1};
RA Guirao-Rico S., Aguade M.;
RT "Molecular evolution of the ligands of the insulin-signaling pathway: dilp
RT genes in the genus Drosophila.";
RL Mol. Biol. Evol. 0:0-0(2010).
RN [3] {ECO:0000313|EMBL:CCF74163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CNIII_1 {ECO:0000313|EMBL:CCF74163.1}, CNIII_15
RC {ECO:0000313|EMBL:CCF74167.1}, CNIII_16 {ECO:0000313|EMBL:CCF74171.1},
RC CNIII_18 {ECO:0000313|EMBL:CCF74175.1}, CNIII_22
RC {ECO:0000313|EMBL:CCF74179.1}, CNIII_35 {ECO:0000313|EMBL:CCF74183.1},
RC CNIII_36 {ECO:0000313|EMBL:CCF74187.1}, CNIII_5
RC {ECO:0000313|EMBL:CCF74191.1}, CNIII_6 {ECO:0000313|EMBL:CCF74195.1},
RC and CNIII_7 {ECO:0000313|EMBL:CCF74199.1};
RA Guirao-Rico S., Aguade M.;
RT "Patterns of nucleotide diversity at the regions encompassing the
RT Drosophila insulin-like peptide (dilp) genes: demography vs positive
RT selection in Drosophila melanogaster.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ANY27240.1}
RP NUCLEOTIDE SEQUENCE.
RA Wan K., Booth B., Spirohn K., Hao T., Hu Y., Calderwood M., Hill D.,
RA Mohr S., Vidal M., Celniker S., Perrimon N.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; KX531430; ANY27240.1; -; mRNA.
DR EMBL; FR751151; CBY85561.1; -; Genomic_DNA.
DR EMBL; HE654170; CCF74163.1; -; Genomic_DNA.
DR EMBL; HE654171; CCF74167.1; -; Genomic_DNA.
DR EMBL; HE654172; CCF74171.1; -; Genomic_DNA.
DR EMBL; HE654173; CCF74175.1; -; Genomic_DNA.
DR EMBL; HE654174; CCF74179.1; -; Genomic_DNA.
DR EMBL; HE654175; CCF74183.1; -; Genomic_DNA.
DR EMBL; HE654176; CCF74187.1; -; Genomic_DNA.
DR EMBL; HE654177; CCF74191.1; -; Genomic_DNA.
DR EMBL; HE654178; CCF74195.1; -; Genomic_DNA.
DR EMBL; HE654179; CCF74199.1; -; Genomic_DNA.
DR RefSeq; NP_648361.1; NM_140104.3.
DR AlphaFoldDB; E7BBS3; -.
DR DNASU; 39152; -.
DR EnsemblMetazoa; FBtr0076372; FBpp0076101; FBgn0044049.
DR GeneID; 39152; -.
DR KEGG; dme:Dmel_CG6736; -.
DR CTD; 39152; -.
DR VEuPathDB; VectorBase:FBgn0044049; -.
DR HOGENOM; CLU_146931_0_0_1; -.
DR OMA; VNGFSHR; -.
DR OrthoDB; 3574766at2759; -.
DR BioGRID-ORCS; 39152; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39152; -.
DR Bgee; FBgn0044049; Expressed in stage 5 embryo (Drosophila) and 29 other cell types or tissues.
DR ExpressionAtlas; E7BBS3; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR043387; INSL3/INSL4.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR10423; INSULIN-LIKE 3; 1.
DR PANTHER; PTHR10423:SF3; INSULIN-LIKE 3; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Secreted {ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..134
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015090290"
FT DOMAIN 28..133
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 72..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 134 AA; 15140 MW; AE8D916950C16075 CRC64;
MSLIRLGLAL LLLLATVSQL LQPVQGRRKM CGEALIQALD VICVNGFTRR VRRSSASKDA
RVRDLIRKLQ QPDEDIEQET ETGRLKQKHT DADTEKGVPP AVGSGRKLRR HRRRIAHECC
KEGCTYDDIL DYCA
//
