ID E7CUK4_PIG Unreviewed; 547 AA.
AC E7CUK4; A0A287A610;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|EMBL:ADK33605.1, ECO:0000313|Ensembl:ENSSSCP00000039302.2};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSSSCP00000039302.2,
GN ECO:0000313|VGNC:VGNC:93334};
GN Synonyms=socs7 {ECO:0000313|EMBL:ADK33605.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ADK33605.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000039302.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000039302.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADK33605.1}
RP NUCLEOTIDE SEQUENCE.
RA Meng F., Li F., Li J., Wang Y.;
RT "Pig Suppressor of Cytokine Signaling 7 (SOCS7) Gene: cDNA Cloning,
RT Functional Characterization and Identification of its Spliced Variants.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000039302.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; HM633191; ADK33605.1; -; mRNA.
DR RefSeq; XP_005654071.1; XM_005654014.2.
DR Ensembl; ENSSSCT00000042121.3; ENSSSCP00000039302.2; ENSSSCG00000018057.5.
DR GeneID; 100514187; -.
DR CTD; 30837; -.
DR VGNC; VGNC:93334; SOCS7.
DR GeneTree; ENSGT00940000156314; -.
DR OrthoDB; 5401079at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000018057; Expressed in oocyte and 43 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF37; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 365..474
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 469..519
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 59497 MW; C2CC8F7CBCA86527 CRC64;
MVFRNVGRPP EEEDAEAAPD PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL
AALGLGQSAG PGVKTVSGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL
ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPMQDLV LPGRLSRGEQ
QQQQQQPPPP PPPPGPLRPL AGPSRKGSLK IRLSRLFRTK SCNGGSGGGD GAGKRPSGEL
AASAGSLTDM GGSAGRELDT GRKPRLTRTQ SAFSPVSFSP LFTGETVSLV DVDISQRGLT
SPHPPTPPPP PRRSLSLLDA FPRIAPTRAA ESLHSQPPQH LQCPLYRPDS SSFAASLREL
EKCGWYWGPM NWEDAEIKLK GKPDGSFLVR DSSDPRYILS LSFRSQGITH HTRMEHYRGT
FSLWCHPKFE DRCQSVVEFI KRAIMHSKNG KFLYFLRSRV PGLPPTPVQL LYPVSRFSNV
KSLQHLCRFR IRQLVRIDHI PDLPLPKPLI SYIRKFYYYD PQEEVYLSLK EAQLISKQKQ
EVLEPST
//
