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Database: UniProt
Entry: E7EKB8_PAEPO
LinkDB: E7EKB8_PAEPO
Original site: E7EKB8_PAEPO 
ID   E7EKB8_PAEPO            Unreviewed;       350 AA.
AC   E7EKB8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=Butanediol dehydrogenase {ECO:0000313|EMBL:ADV15558.1, ECO:0000313|EMBL:AIY08081.1};
DE            EC=1.1.1.4 {ECO:0000313|EMBL:ADV15558.1};
GN   ORFNames=LK13_05500 {ECO:0000313|EMBL:AIY08081.1};
OS   Paenibacillus polymyxa (Bacillus polymyxa).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1406 {ECO:0000313|EMBL:ADV15558.1};
RN   [1] {ECO:0000313|EMBL:ADV15558.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 12321 {ECO:0000313|EMBL:ADV15558.1};
RA   Yu B., Sun J., Zeng A.-P.;
RT   "Genomic analysis of Paenibacillus polymyxa ATCC12321 and functional
RT   characterization of genes for the synthesis of optically active
RT   (2R,3R)-2,3-butanediol.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AIY08081.1, ECO:0000313|Proteomes:UP000031424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF05 {ECO:0000313|EMBL:AIY08081.1,
RC   ECO:0000313|Proteomes:UP000031424};
RX   PubMed=25883277;
RA   Lei M., Lu P., Jin L., Wang Y., Qin J., Xu X., Zhang L., Wang Y.;
RT   "Complete Genome Sequence of Paenibacillus polymyxa CF05, a Strain of Plant
RT   Growth-Promoting Rhizobacterium with Elicitation of Induced Systemic
RT   Resistance.";
RL   Genome Announc. 3:0-0(0).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; HQ730089; ADV15558.1; -; Genomic_DNA.
DR   EMBL; CP009909; AIY08081.1; -; Genomic_DNA.
DR   RefSeq; WP_016821825.1; NZ_UATJ01000003.1.
DR   AlphaFoldDB; E7EKB8; -.
DR   SMR; E7EKB8; -.
DR   GeneID; 66576423; -.
DR   KEGG; ppoy:RE92_19025; -.
DR   PATRIC; fig|1406.49.peg.1195; -.
DR   BRENDA; 1.1.1.4; 683.
DR   Proteomes; UP000031424; Chromosome.
DR   GO; GO:0000721; F:(R,R)-butanediol dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08233; butanediol_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43161:SF23; (R,R)-BUTANEDIOL DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADV15558.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          8..346
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   350 AA;  37847 MW;  F52553B4F44F8456 CRC64;
     MQALRWHGVK DLRLENIEQP AALPGKVKIK VEWCGICGSD LHEYVAGPIF IPENAQHPLT
     GEKAPIVMGH EFSGQVVEIG EGVTKIQVGD RVVVEPVFAC GECDACRQGK YNLCDKMGFL
     GLAGGGGGFS EYVAADEHMV HKIPESVSFE QGALVEPSAV ALYAVRQSQL KVGDKAVVFG
     AGPIGLLVIE ALKASGASEI YAVELSEERK AKAEELGAIV LDPKTYDVVE ELHKRTNGGV
     DVAYEVTGVP PVLTQAIEST KISGQIMIVS IFEKEAPIKP NNIVMKERNL TGIIGYRDVF
     PAVISLMEKG YFPADKLVTK RIKLEEVIEQ GFEGLLKEKN QVKILVSPKA
//
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