ID E7ENX6_HUMAN Unreviewed; 418 AA.
AC E7ENX6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Leucine rich repeat and fibronectin type III domain containing 4 {ECO:0000313|Ensembl:ENSP00000377524.3};
GN Name=LRFN4 {ECO:0000313|Ensembl:ENSP00000377524.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377524.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000377524.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000377524.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP003176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E7ENX6; -.
DR SMR; E7ENX6; -.
DR MassIVE; E7ENX6; -.
DR MaxQB; E7ENX6; -.
DR PeptideAtlas; E7ENX6; -.
DR ProteomicsDB; 17244; -.
DR Antibodypedia; 30278; 81 antibodies from 21 providers.
DR Ensembl; ENST00000393952.3; ENSP00000377524.3; ENSG00000173621.9.
DR UCSC; uc058ebx.1; human.
DR HGNC; HGNC:28456; LRFN4.
DR VEuPathDB; HostDB:ENSG00000173621; -.
DR GeneTree; ENSGT00940000162195; -.
DR HOGENOM; CLU_016998_1_0_1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000173621; Expressed in ganglionic eminence and 139 other cell types or tissues.
DR ExpressionAtlas; E7ENX6; baseline and differential.
DR CDD; cd05764; IgI_SALM5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF3; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7ENX6,
KW ECO:0007829|ProteomicsDB:E7ENX6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..418
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003218969"
FT DOMAIN 281..367
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 418 AA; 44395 MW; E3D6EDD7C569AECE CRC64;
MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT VELRLADNFI
QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS LHLDGNRLVE LGTGSLRGPV
NLQHLILSGN QLGRIAPGAF DDFLESLEDL DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL
IDALPPGAFA QLGQLSRLDL TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC
ELLWLRRLAR PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL
RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT CIATNPAGEA
TARVELRVLA LPHGGNSRPG AAAWPGSPSL VFILSTSGSP VYLEGQGALS SVLASRPG
//
