ID E7ERK4_HUMAN Unreviewed; 297 AA.
AC E7ERK4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Angiopoietin-1 {ECO:0000256|ARBA:ARBA00015279};
GN Name=ANGPT1 {ECO:0000313|Ensembl:ENSP00000429349.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429349.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429349.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000429349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC091010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E7ERK4; -.
DR SMR; E7ERK4; -.
DR MassIVE; E7ERK4; -.
DR PeptideAtlas; E7ERK4; -.
DR ProteomicsDB; 17802; -.
DR Antibodypedia; 4501; 768 antibodies from 40 providers.
DR Ensembl; ENST00000520052.1; ENSP00000429349.1; ENSG00000154188.10.
DR UCSC; uc064ply.1; human.
DR HGNC; HGNC:484; ANGPT1.
DR VEuPathDB; HostDB:ENSG00000154188; -.
DR GeneTree; ENSGT00940000158117; -.
DR HOGENOM; CLU_038628_3_2_1; -.
DR ChiTaRS; ANGPT1; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000154188; Expressed in lower lobe of lung and 173 other cell types or tissues.
DR ExpressionAtlas; E7ERK4; baseline and differential.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 4.10.530.10; Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR19143:SF156; ANGIOPOIETIN-1; 1.
DR PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 1: Evidence at protein level;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|MaxQB:E7ERK4,
KW ECO:0007829|PeptideAtlas:E7ERK4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 76..296
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 2..50
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 297 AA; 34275 MW; 7FFF4A75DE0B0138 CRC64;
MEGKHKEELD TLKEEKENLQ GLVTRQTYII QELEKQLNRA TTNNSVLQKQ QLELMDTVHN
LVNLCTKEVL LKGGKREEEK PFRDCADVYQ AGFNKSGIYT IYINNMPEPK KVFCNMDVNG
GGWTVIQHRE DGSLDFQRGW KEYKMGFGNP SGEYWLGNEF IFAITSQRQY MLRIELMDWE
GNRAYSQYDR FHIGNEKQNY RLYLKGHTGT AGKQSSLILH GADFSTKDAD NDNCMCKCAL
MLTGGWWFDA CGPSNLNGMF YTAGQNHGKL NGIKWHYFKG PSYSLRSTTM MIRPLDF
//
