ID E7ESL9_HUMAN Unreviewed; 576 AA.
AC E7ESL9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSP00000335589.3};
GN Name=AGAP3 {ECO:0000313|Ensembl:ENSP00000335589.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000335589.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000335589.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0007829|PubMed:16964243}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [3] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4] {ECO:0007829|PubMed:19413330}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6] {ECO:0000313|Ensembl:ENSP00000335589.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001295234.1; NM_001308305.1.
DR AlphaFoldDB; E7ESL9; -.
DR SMR; E7ESL9; -.
DR MassIVE; E7ESL9; -.
DR MaxQB; E7ESL9; -.
DR ProteomicsDB; 18018; -.
DR Antibodypedia; 1445; 163 antibodies from 28 providers.
DR DNASU; 116988; -.
DR Ensembl; ENST00000335367.7; ENSP00000335589.3; ENSG00000133612.20.
DR GeneID; 116988; -.
DR UCSC; uc003wjh.1; human.
DR CTD; 116988; -.
DR HGNC; HGNC:16923; AGAP3.
DR VEuPathDB; HostDB:ENSG00000133612; -.
DR GeneTree; ENSGT00940000159586; -.
DR HOGENOM; CLU_473227_0_0_1; -.
DR OrthoDB; 1449795at2759; -.
DR BioGRID-ORCS; 116988; 13 hits in 1154 CRISPR screens.
DR ChiTaRS; AGAP3; human.
DR GenomeRNAi; 116988; -.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000133612; Expressed in right hemisphere of cerebellum and 180 other cell types or tissues.
DR ExpressionAtlas; E7ESL9; baseline and differential.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd04103; Centaurin_gamma; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF2; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 1: Evidence at protein level;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:E7ESL9,
KW ECO:0007829|MaxQB:E7ESL9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REGION 55..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 61786 MW; 1AD4CAE7251CC432 CRC64;
MERGWPQGDS CPGERPAACR RAHSVCDSLD LHGASAGRAA AALQAALCAA SEQPARPRSV
CSGGPEPPPT GARGLLLGLL RPRLGRRGLA PSGPPVSPAP SPASSPAPTR RSRTRGEPTP
RPRPASMTFL EVNRLELAAA EAPGAGLGRA GSAGFLRGAA LWSSQRWPVL RGGRGPEGPR
RGLAALRKSF SFRLRRGQEV RRSESGLLAR PPRARTRSDG DAGSLGAFPS RRDLLGSDAP
RAAPEPGRPR TAAGLWRLLT SRFRRREPAP AAPLWGRRAA AAPELLRAPS DSFVNSQEWT
LSRSVPELKV GIVGNLSSGK SALVHRYLTG TYVQEESPEG GRFKKEIVVD GQSYLLLIRD
EGGPPELQFA AWVDAVVFVF SLEDEISFQT VYNYFLRLCS FRNASEVPMV LVGTQDAISA
ANPRVIDDSR ARKLSTDLKR CTYYETCATY GLNVERVFQD VAQKVVALRK KQQLAIGPCK
SLPNSPSHSA VSAASIPAVH INQATNGGGS AFSDYSSSVP STPSISQREL RIETIAASST
PTPIRKQSKR RSNIFTICAT VSNFSSTKRP FQLLPN
//
