ID E7FA32_DANRE Unreviewed; 748 AA.
AC E7FA32; A0A8M2B459;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=CCR4-NOT transcription complex subunit 10 {ECO:0000256|RuleBase:RU367083};
GN Name=cnot10 {ECO:0000313|Ensembl:ENSDARP00000106673,
GN ECO:0000313|RefSeq:XP_005157919.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060929-368};
GN Synonyms=im:7139356 {ECO:0000313|RefSeq:XP_005157919.1}, zgc:152939
GN {ECO:0000313|RefSeq:XP_005157919.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000106673};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000106673}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000106673};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000106673, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000106673};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005157919.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005157919.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. {ECO:0000256|RuleBase:RU367083}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367083}.
CC Nucleus {ECO:0000256|RuleBase:RU367083}.
CC -!- SIMILARITY: Belongs to the CNOT10 family.
CC {ECO:0000256|ARBA:ARBA00010080, ECO:0000256|RuleBase:RU367083}.
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DR EMBL; BX511173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005157919.1; XM_005157862.4.
DR PaxDb; 7955-ENSDARP00000106673; -.
DR PeptideAtlas; E7FA32; -.
DR Ensembl; ENSDART00000125111; ENSDARP00000106673; ENSDARG00000058528.
DR Ensembl; ENSDART00000125111.3; ENSDARP00000106673.1; ENSDARG00000058528.7.
DR GeneID; 449918; -.
DR AGR; ZFIN:ZDB-GENE-060929-368; -.
DR CTD; 25904; -.
DR ZFIN; ZDB-GENE-060929-368; cnot10.
DR OMA; PECSRMY; -.
DR OrthoDB; 5482679at2759; -.
DR PhylomeDB; E7FA32; -.
DR Proteomes; UP000000437; Chromosome 16.
DR Bgee; ENSDARG00000058528; Expressed in testis and 28 other cell types or tissues.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR039740; CNOT10.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12979; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR PANTHER; PTHR12979:SF5; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|RuleBase:RU367083};
KW Nucleus {ECO:0000256|RuleBase:RU367083};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7FA32};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU367083};
KW Transcription {ECO:0000256|RuleBase:RU367083};
KW Transcription regulation {ECO:0000256|RuleBase:RU367083};
KW Translation regulation {ECO:0000256|RuleBase:RU367083}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82273 MW; CEE7B8CB8C76C7D0 CRC64;
MAETGSDQSG DMKHDIASSP GMSDLEKEVA TNAFEAFKTG SYDESLKYLD NLQELNKEDY
KITMNKAVTE FYKSGQTTSS TLKQTLMTLK NQMHTAVEDI DGLDDVENSI LYYNQAVIHY
HMRQYSEAIC IGEKLYQFLE PFEKFAQAVC FLLVDLYLLT FQPEKALHLL AVLEKLTVKD
GTSKNGKGEN ASSTNKESAA LKAEFTAMIE AAKSKMHQYK VRAYIQMKSL KACKREIKSV
MNTSGNSAPS LFLKSNFEYL RGNYRKAVKL LNSSNIAEHP GPLKTGECVR CMFWNNLGCI
HFAMGKHNLG LFYFKKALQE NDHTCAQIGD GSNAQASKKF SGIPMCALLA NKRYELLYNC
GIQLLHIGRP LAAFECLMEA VQVYHSNPRL WLRLAECCIT ANKGSSEQET KGLPSKKGIV
QAVVGQGYHR KIVLASQSTQ NTIYSEAQSA AIPVASMEFA AICLRNALLL LPEHQQHDSK
PDNGSKSYSQ SGGTESGSET SDACSGKTQE GDKFIPAAPS SPLRKQEVEN LRCSILACSA
YVALALGDNL MALNHAEKLL HQAKLSGSLK FLGHLYAAEA LISLDRISDA IAHLNPENVT
DVSLGVSSSE QDQGSDKGDL EPVESSGKQT PLCYPSSVSS ARATMLFNLG SAYCLRSEYE
KARKCLHQAA SMVNTKEIPP EAILLGVYLE LQNGNTQLAL QIIKRNQLLP SVKPGSSPDF
RKKPLSFQST QPVQPIQTPS SFTQVQRK
//
