ID E7FAI5_DANRE Unreviewed; 632 AA.
AC E7FAI5; A0A8M2BD97;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Receptor-like tyrosine kinase {ECO:0000313|Ensembl:ENSDARP00000106622};
DE SubName: Full=Tyrosine-protein kinase RYK isoform X1 {ECO:0000313|RefSeq:XP_005165988.1};
GN Name=ryk {ECO:0000313|Ensembl:ENSDARP00000106622,
GN ECO:0000313|RefSeq:XP_005165988.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070209-277};
GN Synonyms=wu:fb37b12 {ECO:0000313|RefSeq:XP_005165988.1}, wu:fi05b06
GN {ECO:0000313|RefSeq:XP_005165988.1}, zgc:158381
GN {ECO:0000313|RefSeq:XP_005165988.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000106622};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000106622}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000106622};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000106622, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000106622};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_005165988.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005165988.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR EMBL; BX890558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005165988.1; XM_005165931.4.
DR PaxDb; 7955-ENSDARP00000106622; -.
DR Ensembl; ENSDART00000128985; ENSDARP00000106622; ENSDARG00000007231.
DR Ensembl; ENSDART00000128985.4; ENSDARP00000106622.2; ENSDARG00000007231.11.
DR GeneID; 558502; -.
DR AGR; ZFIN:ZDB-GENE-070209-277; -.
DR CTD; 6259; -.
DR ZFIN; ZDB-GENE-070209-277; ryk.
DR eggNOG; KOG1024; Eukaryota.
DR OMA; CWAMSPD; -.
DR OrthoDB; 1614410at2759; -.
DR PhylomeDB; E7FAI5; -.
DR TreeFam; TF317402; -.
DR Reactome; R-DRE-201681; TCF dependent signaling in response to WNT.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000007231; Expressed in gastrula and 30 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0017147; F:Wnt-protein binding; IDA:ZFIN.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IMP:ZFIN.
DR GO; GO:0060026; P:convergent extension; IGI:ZFIN.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IMP:ZFIN.
DR GO; GO:0060030; P:dorsal convergence; IMP:ZFIN.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:ZFIN.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; IMP:ZFIN.
DR CDD; cd05043; PTK_Ryk; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000313|RefSeq:XP_005165988.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|RefSeq:XP_005165988.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..632
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116669"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..188
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 355..628
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 195..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 70568 MW; B9EEC367753A40AC CRC64;
MFLPARGSVG GAASAVSRGW PHTVQWRLVG FFLLLLLEGA RCLANPSNSP GINNNNRPNV
NIFMSEEEVK KLLGLDAELY YVRDDVVNHY ALSFVLPVPS DTNSLHFTWH SSSKVDYRLG
FHVENTSAMD QPQSNISVQG EVPRTRSVFR VDLFCSGKAD GEAVLTVQLN LSTAANFTVL
NFKRRKMCYR RIEQPEPPKT LPFPNTTIQR IDASSPNAPT TSTRVFYISV CVCCIVIFLV
AIILAVLHLH SMKRVEMDDS VSDSGSSQGL SQPSTQTTQY LRADTPNNAT PVTNAQTGSA
PMLQLAGASF PHPGAPSHET KSYPSLRIEK NDLRSVTLLE AKAKVKDIAI SRERVTLRDV
LHEGTFGRIF HGVLLDEKDP SKEKQVFVKA VKDHASEVQV TMMLTESCKL RGLHHRNLLP
ISHVCIEDGE KPMVLLPYMN WGNLKLFLRQ CKLAEANNPQ AISQQDLVHM AIQISCGMSY
LARREVIHKD LAARNCVIDN SMQVKITDNA LARDLFPMDY HCLGDNENRP VRWMALESLL
NNDFSSASDV WAFGVTLWEL MTLGQTPYVD IDPFEMAAYL KDGYRIAQPI NCPDELFAVM
ACCWALDPEE RPKFQQLVQC LTEFHAALGA YV
//
