ID E7GT74_CLOSY Unreviewed; 702 AA.
AC E7GT74;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=RND superfamily Drug exporter {ECO:0000313|EMBL:EGA91951.1};
GN ORFNames=HMPREF9474_04119 {ECO:0000313|EMBL:EGA91951.1};
OS [Clostridium] symbiosum WAL-14163.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=742740 {ECO:0000313|EMBL:EGA91951.1, ECO:0000313|Proteomes:UP000002970};
RN [1] {ECO:0000313|EMBL:EGA91951.1, ECO:0000313|Proteomes:UP000002970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAL-14163 {ECO:0000313|EMBL:EGA91951.1,
RC ECO:0000313|Proteomes:UP000002970};
RA Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA Molitoris D.R., Vaisanen M.L., Daigneault M., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA White J., Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium symbiosum strain WAL-14163.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGA91951.1}.
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DR EMBL; ADLQ01000094; EGA91951.1; -; Genomic_DNA.
DR AlphaFoldDB; E7GT74; -.
DR STRING; 1512.GCA_900049235_04450; -.
DR eggNOG; COG1033; Bacteria.
DR HOGENOM; CLU_007352_0_0_9; -.
DR Proteomes; UP000002970; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002970};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..306
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 433..687
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 683..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 78459 MW; AE79677BF48279FB CRC64;
MIAVLLSMLA APFVNINYDL TRYLPDTVQS KAGLDLMEEK FGYPGTGRVM IEDVTLYEAK
QYKDKLEKVD GVDQIMWLDT GTDVFSSDAF INFNSIDDYY KDGSAVMDIV FEKGDTSRKT
SRAIDAMQEI TGEKGHYVGM AVQNKSLAEN VTKEMKLILT LGVLMIFIIL CLTTNSWFEP
VLYLIVMGVA ILINKGTNIF LGEISFLTNS VSAVLQLAVS MDYSIFLIHA FTREKNKGLD
QMTALTNAIN EALNSIFASS LTTIVGFIVL AFMKFNIGFD MGIVLAKGII FSLLTVVFFM
PAMILRLTPM IEKTGHRSFM PGFDKLSRGI YRIRYGVLIF VAIFVIPAYT AQNMNRFLFG
NDAVGASEGT KVYDDEQLIN AKFGRSNMMM ALVPNTSLID EKAFTDEVEA LAYTKSVTSM
AGSLPDGVPE EFLPKSITEQ LHKNDYSRIL IYVRSKGESK LAYQCSDEIQ ALMKKYYPEN
SYLVGTTPST QDIETTITKD YSRVNVLSLL GVFFVVMFSF KSVAIPVIIM IPIEVAIFIN
MAVPYIKGDT MIFMGYIIVS CIQLGATVDY AILTTNNYLE CRKQAEKREA AIQALNMSIP
AILTSGSILT IVGYILYNIS SVAAIGDLGH LIGRGAWMSM LLVCTLLPAF LVLFDNILMD
NEFERIRKFF EKRRMRRRER FRRMAGKVKP GKNGSGEDKK EA
//
