ID E7RNN2_9BACT Unreviewed; 698 AA.
AC E7RNN2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Peptidase family M3 {ECO:0000313|EMBL:EFZ37325.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:EFZ37325.1};
GN Name=dcp {ECO:0000313|EMBL:EFZ37325.1};
GN ORFNames=HMPREF0663_10783 {ECO:0000313|EMBL:EFZ37325.1};
OS Hoylesella oralis ATCC 33269.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Hoylesella.
OX NCBI_TaxID=873533 {ECO:0000313|EMBL:EFZ37325.1, ECO:0000313|Proteomes:UP000005580};
RN [1] {ECO:0000313|EMBL:EFZ37325.1, ECO:0000313|Proteomes:UP000005580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33269 {ECO:0000313|EMBL:EFZ37325.1,
RC ECO:0000313|Proteomes:UP000005580};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ37325.1}.
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DR EMBL; AEPE02000003; EFZ37325.1; -; Genomic_DNA.
DR RefSeq; WP_004367989.1; NZ_GL833116.1.
DR AlphaFoldDB; E7RNN2; -.
DR STRING; 28134.SAMN05444288_2304; -.
DR eggNOG; COG0339; Bacteria.
DR HOGENOM; CLU_001805_4_0_10; -.
DR Proteomes; UP000005580; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06456; M3A_DCP; 1.
DR Gene3D; 1.10.1370.40; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR034005; M3A_DCP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR43660; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR43660:SF1; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000005580};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 240..688
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 698 AA; 80868 MW; 773AF12E9324FAF9 CRC64;
MNEKNIENTE HQNPFFLPYE TPHNTVPFDR IRTSDYEKAF MEGIQRDDEE IEKITNNPDE
PTFDNTIIHV DTSKGEHYYD LLDRVSNVFS CMLSAETNDE LDELAQKMSP ILTKHANDVM
LNERMFARVK HVYQHPDRKL SSEEQMLLDK CYDGFVRSGA LLNEAGKKQL RQLTEEAAML
SLQFSQNLLK ENKAFELHIT DEKQLDGLPE TAREAAALAA KEKGSEGWIF TLDFPSFSPF
MTYSTQRDLR KRMYMARNTE CTHDNTENNL DICKRLINLR REIAQLLGYD TYADYVLKHR
MASNVGNVYK LLDELIDAYK PAAQKEVAEI EAMAKQMEGS DFELMPWDFG YYSHKLQMEK
YNIDAEMLRP YFELSNVIRG VFGLATRLYG ITFEENKDIP VYHKDVKAYD VFDKDGSYLA
VLYTDFHPRK GKQGGAWMTE FQGQWIDHKG NNVRPHASLV MNFTKPTADK PALLTLGEVE
TFLHEFGHSL HGIFANTRFE SLSGTNVWWD FVELPSQFME NFAVEKEFLR TFAFHYRTGE
VIPDDLIERI IRSRNFNAAY GCMRQVAFCL LDMAYYTKTE AFTDDIIPFE KQAWKRAMVT
PQLPDTCMTT QFSHIMAGGY AAGYYSYKWA EVLDADTFGV FKRNGIFDQK TAQSFRDNIL
SRGGTEHPMI LYKRFRGQEP TIQALLERDG IGKTKIEI
//
