ID E8JYU2_9STRE Unreviewed; 360 AA.
AC E8JYU2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Creatinase {ECO:0000313|EMBL:EFX37474.1};
DE EC=3.4.13.9 {ECO:0000313|EMBL:EFX37474.1};
GN Name=pepQ {ECO:0000313|EMBL:EFX37474.1};
GN ORFNames=HMPREF9423_0458 {ECO:0000313|EMBL:EFX37474.1};
OS Streptococcus infantis ATCC 700779.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889204 {ECO:0000313|EMBL:EFX37474.1, ECO:0000313|Proteomes:UP000002815};
RN [1] {ECO:0000313|EMBL:EFX37474.1, ECO:0000313|Proteomes:UP000002815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700779 {ECO:0000313|EMBL:EFX37474.1,
RC ECO:0000313|Proteomes:UP000002815};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX37474.1}.
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DR EMBL; AEVD01000004; EFX37474.1; -; Genomic_DNA.
DR RefSeq; WP_006148155.1; NZ_GL732439.1.
DR AlphaFoldDB; E8JYU2; -.
DR GeneID; 29747707; -.
DR PATRIC; fig|889204.5.peg.254; -.
DR eggNOG; COG0006; Bacteria.
DR HOGENOM; CLU_017266_4_2_9; -.
DR Proteomes; UP000002815; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProt.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:UniProt.
DR GO; GO:0102009; F:proline dipeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046914; F:transition metal ion binding; IEA:UniProt.
DR CDD; cd01092; APP-like; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001714; Pept_M24_MAP.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR46112; AMINOPEPTIDASE; 1.
DR PANTHER; PTHR46112:SF10; DIPEPTIDASE YKVY-RELATED; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR PRINTS; PR00599; MAPEPTIDASE.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 4: Predicted;
KW Dipeptidase {ECO:0000313|EMBL:EFX37474.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EFX37474.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:EFX37474.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002815}.
FT DOMAIN 4..134
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 142..343
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
SQ SEQUENCE 360 AA; 40216 MW; AB6A042AFA17BE4E CRC64;
MSKLQQIVTY LESEKLDVAV VSDPVTINYL TGFYSDPHER QMFLFVLGDQ EPLLFVPALE
VERATSTVSF PVVGYVDSEN PWKKIQNALP QLDFKRVAVE FDNLILTKYH GLKTVFESAE
FENLTPLIQR MRLIKSADEV QKMMVAGIYA DKSVKVGFDN ISLDNTETDI IAQIDFAMKR
EGYEMSFDTM VLTGDNAANP HGIPGANKVE NNALLLFDLG VMVNGYASDM TRTVAVGKPD
QFKKDIYNLT LEAQQAALDF IKPGVTAHEV DRAAREVIEK AGYGEYFNHR LGHGIGMDVH
EFPSIMEGND MVIEEGMCFS VEPGIYIPGK VGVRIEDCGV VTKDGFDLFT NTSKDLLYFD
//
