ID E8JZP9_9STRE Unreviewed; 559 AA.
AC E8JZP9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=FbpA {ECO:0000313|EMBL:EFX37068.1};
GN Synonyms=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=HMPREF9423_0712 {ECO:0000313|EMBL:EFX37068.1};
OS Streptococcus infantis ATCC 700779.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889204 {ECO:0000313|EMBL:EFX37068.1, ECO:0000313|Proteomes:UP000002815};
RN [1] {ECO:0000313|EMBL:EFX37068.1, ECO:0000313|Proteomes:UP000002815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700779 {ECO:0000313|EMBL:EFX37068.1,
RC ECO:0000313|Proteomes:UP000002815};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX37068.1}.
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DR EMBL; AEVD01000005; EFX37068.1; -; Genomic_DNA.
DR AlphaFoldDB; E8JZP9; -.
DR eggNOG; COG1293; Bacteria.
DR HOGENOM; CLU_022481_2_1_9; -.
DR Proteomes; UP000002815; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.970.40; fibrinogen binding protein from staphylococcus aureus domain like; 1.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000002815};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 443..528
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 278..316
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 559 AA; 64411 MW; 0FB2AE8AE4E636E1 CRC64;
MEYIHKERTM SFDGFFLHHM VEELRAKLLN GRIQKINQPF DQELVLQIRS NRQSHRLLLS
AHPVFGRIQL TETTFENPAQ PSTFIMVLRK YLQGAVIESI EQIENDRIVE ITVSNKNEIG
DDIQATLIIE IMGKHSNILL VDKSSSKVLE VIKHIGFSQN SYRTLLPGAT YIAPPSTEAL
NPFTIKDEKL FEILQTQELT AKNLQSLFQG LGRDTAIELE NLLTDDRFSN FRDFFKQETN
PCLTDKSFSC VPFSTKIEGH FSSLSQLLDV FYKDKAERDR VKQQASELIR RVENELQKNR
QKLKKQEKEL LATENAEEFR QKGELLTTFL HQVPNDQDQV VLDNYYTNQP VTIALDKALT
PNQNAQRYFK RYQKLKEAVK YLTDLIEETK STILYLESVE TVLNQAGLDE IAEIREELIQ
TGFIRRRQRE KIQKRKKPEK YLASDGKTII LVGRNNLQNE ELTFKIARKE ELWFHAKNIP
GSHVVISGNL NPSDEVKTDA AELAAYYSKG RLSNLVQVDM IEVKKLNKPT GGKPGFVTYT
GQKTLRVTPD SEKIESMKL
//
