ID E8K0C9_9STRE Unreviewed; 419 AA.
AC E8K0C9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Xanthine permease {ECO:0000313|EMBL:EFX36708.1};
GN Name=pbuX {ECO:0000313|EMBL:EFX36708.1};
GN ORFNames=HMPREF9423_0942 {ECO:0000313|EMBL:EFX36708.1};
OS Streptococcus infantis ATCC 700779.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=889204 {ECO:0000313|EMBL:EFX36708.1, ECO:0000313|Proteomes:UP000002815};
RN [1] {ECO:0000313|EMBL:EFX36708.1, ECO:0000313|Proteomes:UP000002815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700779 {ECO:0000313|EMBL:EFX36708.1,
RC ECO:0000313|Proteomes:UP000002815};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX36708.1}.
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DR EMBL; AEVD01000007; EFX36708.1; -; Genomic_DNA.
DR RefSeq; WP_006148608.1; NZ_GL732439.1.
DR AlphaFoldDB; E8K0C9; -.
DR GeneID; 29746431; -.
DR PATRIC; fig|889204.5.peg.88; -.
DR eggNOG; COG2233; Bacteria.
DR HOGENOM; CLU_017959_8_2_9; -.
DR Proteomes; UP000002815; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002815};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 419 AA; 44179 MW; 9E42295217479AC8 CRC64;
MNQKENHSKA AVLGLQHLLA MYSGSILVPI MIAGALGYSP QQLTYLISTD IFMCGVATLL
QLQLNKYFGV GLPIVLGVAF QSVAPLIMIG QSHGSGAMFG ALIASGIYVV LVAGVFSKVA
NLFPSIVTGS VITTIGLTLI PVAIGNMGNN VEKPTGQSLA LATITILIIL LVNIFTKGFI
KSISILIGLI AGTIIAATMG LVDFSPVAEA PLVHIPTPFY FGAPQFEISS IVMMCIIATV
SMVESTGVYL ALSDITKDPI DSIRLRNGYR AEGLAVLLGG LFNTFPYTGF SQNVGLVKLS
GIRTRLPIYY AAGFLILLGL LPKFGALAQI IPSPVLGGAM LVMFGFVSLQ GMQILSRVDF
EHNEHNFLIA AVSIAAGVGL NGSNLFNTLP TELQMFFSNG IVIASTVAII LNAILNRKK
//
