ID E8K9D6_9STRE Unreviewed; 271 AA.
AC E8K9D6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN Name=spoIIIJ {ECO:0000313|EMBL:EFX41371.1};
GN Synonyms=yidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN ORFNames=HMPREF9180_0091 {ECO:0000313|EMBL:EFX41371.1};
OS Streptococcus peroris ATCC 700780.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888746 {ECO:0000313|EMBL:EFX41371.1, ECO:0000313|Proteomes:UP000010304};
RN [1] {ECO:0000313|EMBL:EFX41371.1, ECO:0000313|Proteomes:UP000010304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700780 {ECO:0000313|EMBL:EFX41371.1,
RC ECO:0000313|Proteomes:UP000010304};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01811}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX41371.1}.
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DR EMBL; AEVF01000001; EFX41371.1; -; Genomic_DNA.
DR RefSeq; WP_006144726.1; NZ_GL732463.1.
DR AlphaFoldDB; E8K9D6; -.
DR STRING; 888746.HMPREF9180_0091; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_0_9; -.
DR Proteomes; UP000010304; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
KW Chaperone {ECO:0000256|HAMAP-Rule:MF_01811};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01811};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01811}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..271
FT /note="Membrane protein insertase YidC"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008953633"
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 156..179
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 200..223
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT DOMAIN 55..237
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 271 AA; 30759 MW; 860861620E2F6A6A CRC64;
MKKKLQLTSL IGLSLLVMTA CATSEVSADS ADFWSKLVYF FAVTIRFLSF DISIGLGIIL
FTVLIRTILL PVFQTQMVAS RKMQEAQPRI KELRERYPGR DMESRTKLDQ ETRKLFKELG
IKQSATFWPL LIQMPILLAL FQALSNVDFL KTGHFLWFNL GGADTTFVLP ILAALFTFFS
SWLSNKALPE KNAAMTGMMY GMPVIIFFFA ISAPSGVALY WAVSNAYQVL QTYLLNNPFK
IIAEREADLQ AKKDLESKKR KALKKAQKKK K
//
