ID E8KBE5_9STRE Unreviewed; 347 AA.
AC E8KBE5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=2-oxo acid dehydrogenase acyltransferase (Catalytic domain) {ECO:0000313|EMBL:EFX40569.1};
DE EC=2.3.1.12 {ECO:0000313|EMBL:EFX40569.1};
GN Name=sucB {ECO:0000313|EMBL:EFX40569.1};
GN ORFNames=HMPREF9180_0800 {ECO:0000313|EMBL:EFX40569.1};
OS Streptococcus peroris ATCC 700780.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888746 {ECO:0000313|EMBL:EFX40569.1, ECO:0000313|Proteomes:UP000010304};
RN [1] {ECO:0000313|EMBL:EFX40569.1, ECO:0000313|Proteomes:UP000010304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700780 {ECO:0000313|EMBL:EFX40569.1,
RC ECO:0000313|Proteomes:UP000010304};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA
CC + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein];
CC Xref=Rhea:RHEA:17017, Rhea:RHEA-COMP:10475, Rhea:RHEA-COMP:10478,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:83100,
CC ChEBI:CHEBI:83111; EC=2.3.1.12;
CC Evidence={ECO:0000256|ARBA:ARBA00043782};
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX40569.1}.
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DR EMBL; AEVF01000009; EFX40569.1; -; Genomic_DNA.
DR RefSeq; WP_006145563.1; NZ_GL732463.1.
DR AlphaFoldDB; E8KBE5; -.
DR STRING; 888746.HMPREF9180_0800; -.
DR eggNOG; COG0508; Bacteria.
DR HOGENOM; CLU_016733_2_1_9; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000010304; Unassembled WGS sequence.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR045257; E2/Pdx1.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF90; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 2.
DR PROSITE; PS51826; PSBD; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EFX40569.1};
KW Transferase {ECO:0000313|EMBL:EFX40569.1}.
FT DOMAIN 7..44
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT DOMAIN 50..87
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 347 AA; 38088 MW; F042266D2B9360E3 CRC64;
MADDKLRATP AARKLADDLG INLYDISGSG ANGRVHKEDV ETYKDTNVVR ISPLAKRIAL
EHNIAWQEIQ GTGHRGKIMK KDVLAYLPEN IENDTIKSPA QIEKVEEVPD NVTPYGEIER
IPMTPMRKVI AQRMVESYLT APTFTLNYDV DMSEMLALRK KVLDPIMEAT GKKITVTDLL
SLAVVKTLMK HPYINASLTE DGKTIITHNY VNLAMAVGMD NGLMTPVVYN AEKMTLSELV
VAFKDVIGRT LDGKLAPSEL QNSTFTISNL GMFGVQSFGP IINQPNSAIL GVSSTVEKPV
VVNGEIVIRP IMSLGLTIDH RVVDGMAGAK FMKDLKALIE NPISMLV
//
