ID E8KH12_9PAST Unreviewed; 586 AA.
AC E8KH12;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HMPREF0027_1129 {ECO:0000313|EMBL:EFX91812.1};
OS Actinobacillus ureae ATCC 25976.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=887324 {ECO:0000313|EMBL:EFX91812.1, ECO:0000313|Proteomes:UP000005467};
RN [1] {ECO:0000313|EMBL:EFX91812.1, ECO:0000313|Proteomes:UP000005467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25976 {ECO:0000313|EMBL:EFX91812.1,
RC ECO:0000313|Proteomes:UP000005467};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFX91812.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEVG01000077; EFX91812.1; -; Genomic_DNA.
DR RefSeq; WP_005622749.1; NZ_GL831080.1.
DR AlphaFoldDB; E8KH12; -.
DR REBASE; 32879; M.Aur25976ORF1129P.
DR HOGENOM; CLU_020164_2_1_6; -.
DR Proteomes; UP000005467; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF16; TYPE III RESTRICTION-MODIFICATION ENZYME STYLTI MOD SUBUNIT; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFX91812.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFX91812.1}.
FT DOMAIN 89..413
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
FT REGION 239..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 68060 MW; 2EBA0695BF479D0A CRC64;
MPEIFSEGKI DFDKFQQLFS DKISTEPDRY HLNWAGKSQA YQQLQIPTQK TLTPCVEESV
DFEQTQNILI EGENLDVLKA LQKSYFNSIK MIYIDPPYNT GNDFVYNDNF AQSQTDYQAQ
TGEIGEDGFL KKAFRKNAKE NGHFHSNWLN MMLPRLHLAR NLLKDDGVIF ISIDDNEQAQ
LKLLCGEVFG EENFVANVIW KHTEQNKNDE KYFSRQFNYL LVYKKSNALN KFRFPRTEQD
NVNYSNPDND PKGKWRSGDV RSPNFRKTLC FNITTPSGKI ISPPDNGWRW NEESIKEKIA
TGEIIFIADE TKIVRKIYLS EQEGRVPENL WQGELSGTTR ISNAEIKDIF ENAIFDTPKP
TRFLKRIMEL FHFDKDYLVL DFFAGSSTTA HAVMQLNAED NGNRRFICVQ LPEETDEKSE
AYKAGFKNIA EISKERIRRA GSQILQKNEE NRPLDVGFKV FKLTDSHFKQ WQSPTAENLA
QQLEMFIDNV KENAEPQAML YEILLRLGLK LTCNVRYENN IFWIEDEKSQ HYAILLEHID
ENLLNSVINV QPQKVVALDR LFAGNYALKK NAELQMKDAN IAFFVI
//