ID E8QYB8_ISOPI Unreviewed; 494 AA.
AC E8QYB8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dihydropteroate synthase DHPS {ECO:0000313|EMBL:ADV63113.1};
GN OrderedLocusNames=Isop_2542 {ECO:0000313|EMBL:ADV63113.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV63113.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV63113.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
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DR EMBL; CP002353; ADV63113.1; -; Genomic_DNA.
DR AlphaFoldDB; E8QYB8; -.
DR STRING; 575540.Isop_2542; -.
DR KEGG; ipa:Isop_2542; -.
DR eggNOG; COG0294; Bacteria.
DR HOGENOM; CLU_041129_0_0_0; -.
DR InParanoid; E8QYB8; -.
DR OrthoDB; 4029442at2; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProt.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR InterPro; IPR045031; DHP_synth-like.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR045406; DUF6513.
DR InterPro; IPR000489; Pterin-binding_dom.
DR PANTHER; PTHR20941; FOLATE SYNTHESIS PROTEINS; 1.
DR PANTHER; PTHR20941:SF1; FOLIC ACID SYNTHESIS PROTEIN FOL1; 1.
DR Pfam; PF20123; DUF6513; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008631}.
FT DOMAIN 109..332
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
FT REGION 451..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 53579 MW; 895BA234CCFFD284 CRC64;
MNDAPRYLFV TGRLAEFALR AVVEELGPKV GFVGEVAVLP ISVAALMPPA WVARHLEVPP
GVVKVVLPGY CRGDLEPIVQ KVGAGVEVVR GPLDLRDLPL FFGGGDTRKH GYGAFDIEIL
AEINHAPTLS LAEIVARGEE LAAQGADVID LGCDPGGPWS GVAEAVTALK DQGLRVSIDS
LDPREIAPAA RAGAELVLSV NATNRDHAPD WGVEVVVIPD RPGTLEGLEE TAEFLESRGV
AVRLDPILEP IGFGFAASLG RYLEVRRRYP AAELMMGVGN LTELTDVDSA GVNVLLAGFC
QEVGIRSVLT TQVINWARSS VKELDLARRL VHHAVVHKTL PKHLEPGLVM LRDPKVPRLG
AEALAELAKR ITDPNFRIFA EDGRIHVING SMHLIGDDPF ELFEQTGVEE PSHAFYLGYE
MMKAKTALTL GKHYRQDQAL DWGFLTEPEL SHRERRKARG DQPVRRAPRG RRASLSVVEE
TTGDTSTPSQ GDAR
//
