ID E8R5D4_ISOPI Unreviewed; 367 AA.
AC E8R5D4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen {ECO:0000313|EMBL:ADV60675.1};
GN OrderedLocusNames=Isop_0078 {ECO:0000313|EMBL:ADV60675.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV60675.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV60675.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR EMBL; CP002353; ADV60675.1; -; Genomic_DNA.
DR RefSeq; WP_013562964.1; NC_014962.1.
DR AlphaFoldDB; E8R5D4; -.
DR STRING; 575540.Isop_0078; -.
DR KEGG; ipa:Isop_0078; -.
DR eggNOG; COG1225; Bacteria.
DR eggNOG; COG3128; Bacteria.
DR HOGENOM; CLU_062430_0_0_0; -.
DR InParanoid; E8R5D4; -.
DR OrthoDB; 255432at2; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008631};
KW Vitamin C {ECO:0000256|ARBA:ARBA00022896}.
FT DOMAIN 255..349
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 367 AA; 41152 MW; BD5B6F2D96CE21D7 CRC64;
MLTVGDPAPW FHARSSVNPN FHFDTAAGRY LVLCFFGSSS DPAARRVLSD LEHATDLSNI
VNCCFFGVSR DPADEHEARL PTGKPGLIWF WDFDNAIGRL YGVPDSQTPR KDDAAEGDRF
ASQITYVLDP RLRVVARVPF APDPARHVPN LVRIVRALPP VSSLAEAHAP VLVVPHIFEP
HFCRQLIEIY EADGGYESGF MREVGGKTVP VHDHSHKRRR DCEIKDLQVI QACQMRLKRR
LIPEIHKSFQ FEATRIERHI VACYDASTGG HFRAHRDNTT KGTAHRRFAI SLNLNDDFQG
GDLRFAEFGP RTYRAPVGGA VVFSCSLLHE ATPVTAGKRY AFLPFLYDDV AAEIRRRNAQ
FLAPGPN
//
