ID E8R735_DESM0 Unreviewed; 217 AA.
AC E8R735;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=3-hexulose-6-phosphate synthase {ECO:0000313|EMBL:ADV64468.1};
DE EC=4.1.2.43 {ECO:0000313|EMBL:ADV64468.1};
GN OrderedLocusNames=Desmu_0149 {ECO:0000313|EMBL:ADV64468.1};
OS Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Desulfurococcus.
OX NCBI_TaxID=765177 {ECO:0000313|EMBL:ADV64468.1, ECO:0000313|Proteomes:UP000001068};
RN [1] {ECO:0000313|Proteomes:UP000001068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC {ECO:0000313|Proteomes:UP000001068};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA Chertkov O., Held B., Brettin T., Detter J.C., Tapia R., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Wirth R., Bilek Y., Hader T., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Desulfurococcus mucosus DSM 2162.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV64468.1, ECO:0000313|Proteomes:UP000001068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35584 / DSM 2162 / JCM 9187 / O7/1
RC {ECO:0000313|Proteomes:UP000001068};
RX PubMed=21677854; DOI=10.4056/sigs.1644004;
RA Wirth R., Chertkov O., Held B., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Liolios K., Ioanna P., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Bilek Y., Hader T., Rohde M., Spring S., Sikorski J., Goker M., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P.;
RT "Complete genome sequence of Desulfurococcus mucosus type strain (O7/1).";
RL Stand. Genomic Sci. 4:173-182(2011).
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DR EMBL; CP002363; ADV64468.1; -; Genomic_DNA.
DR AlphaFoldDB; E8R735; -.
DR STRING; 765177.Desmu_0149; -.
DR KEGG; dmu:Desmu_0149; -.
DR eggNOG; arCOG00053; Archaea.
DR HOGENOM; CLU_081825_1_1_2; -.
DR OrthoDB; 15246at2157; -.
DR Proteomes; UP000001068; Chromosome.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ADV64468.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001068}.
FT DOMAIN 4..211
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 217 AA; 23110 MW; ABE7FA8973A31EF2 CRC64;
MDRILQVALD LTKLPEAVEI ATKIASHTSC RNIWLEVGTP LLKAWGLIAV KAVKNLSNCF
VVVDTKTMDV PAIEGGMLLD AGGDAFTVLG VADDDVVKEA VETARARGKL VVADLISHPD
PLKRAVELDR LGVDVVLYHV GISVQRSRRV TVAQLLREIE GLRRNVSARI AVAGGIKPGD
VKGLIASGAD IVVVGGAITK AENPVQVVER ILEEMNT
//
