ID E8RM64_ASTEC Unreviewed; 405 AA.
AC E8RM64;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ADU12756.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:ADU12756.1};
GN OrderedLocusNames=Astex_1078 {ECO:0000313|EMBL:ADU12756.1};
OS Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / KCTC 12464 /
OS NCIMB 9791 / VKM B-1370 / CB 48).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Asticcacaulis.
OX NCBI_TaxID=573065 {ECO:0000313|EMBL:ADU12756.1, ECO:0000313|Proteomes:UP000001492};
RN [1] {ECO:0000313|Proteomes:UP000001492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15261 / DSM 4724 / KCTC 12464 / NCIMB 9791 / VKM B-1370 /
RC CB 48 {ECO:0000313|Proteomes:UP000001492};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Teshima H., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA Brun Y.V., Woyke T.;
RT "Complete sequence of chromosome 1 of Asticcacaulis excentricus CB 48.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; CP002395; ADU12756.1; -; Genomic_DNA.
DR AlphaFoldDB; E8RM64; -.
DR STRING; 573065.Astex_1078; -.
DR KEGG; aex:Astex_1078; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_2_3_5; -.
DR Proteomes; UP000001492; Chromosome 1.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ADU12756.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001492};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ADU12756.1}.
FT DOMAIN 9..232
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 95
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 405 AA; 42265 MW; 6C621F1C12D06644 CRC64;
MASLIPGAYI YDAVRTPRGK GKKDGSLHEI TALDLSRQVL KGLKDRNGLD TALVDDVAFG
CVTPVGEQGG DIARAAVLAA GYAETTGGIQ VNRFCASGLE AINIAAGKVI SGEATMAIGG
GVEAMSRVPM GSDGGAWAID VNAAFPTYFV PQGVSADMIA TKWGFSRADV DAYAVESHKR
SAQSWAEGRF KKSILPVKDQ MGVTRLDYDE TIRPNTDMQT LGGLNPSFAM MGEMAFDAVI
NQRYPEIERV NHVHTPGNSS AIVDGAAAVL IGSAEAAALS GLKPRARIKG MASIGSEPSI
MLTGPSFATE KVLKKLGMSV SDIDLYELNE AFASVVLRYM QALDIPHDKI NVCGGAIAMG
HPLGATGAMI LGTVLDELER TGKGTALVTL CVGGGMATAT VIERI
//
