ID E8T6D9_THEA1 Unreviewed; 460 AA.
AC E8T6D9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Peptidase U62 modulator of DNA gyrase {ECO:0000313|EMBL:ADU96723.1};
GN OrderedLocusNames=Theam_0756 {ECO:0000313|EMBL:ADU96723.1};
OS Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1).
OC Bacteria; Aquificota; Aquificae; Desulfurobacteriales;
OC Desulfurobacteriaceae; Thermovibrio.
OX NCBI_TaxID=648996 {ECO:0000313|EMBL:ADU96723.1, ECO:0000313|Proteomes:UP000006362};
RN [1] {ECO:0000313|EMBL:ADU96723.1, ECO:0000313|Proteomes:UP000006362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15698 / JCM 12110 / HB-1
RC {ECO:0000313|Proteomes:UP000006362};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.;
RT "Complete sequence of chromosome of Thermovibrio ammonificans HB-1.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP002444; ADU96723.1; -; Genomic_DNA.
DR RefSeq; WP_013537509.1; NC_014926.1.
DR AlphaFoldDB; E8T6D9; -.
DR STRING; 648996.Theam_0756; -.
DR KEGG; tam:Theam_0756; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_0; -.
DR OrthoDB; 9803213at2; -.
DR Proteomes; UP000006362; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 24..87
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 112..219
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 226..458
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 460 AA; 49864 MW; B1AE5FDDA6831C18 CRC64;
MVDFKELGEF GARELKKRGA DFGDLFFERR FTFSGKCEEN RIENLSNGIE VGVGIRFIKN
FKTYYGFTNK LSQKAILEVI ENLAAAAAAE KEVTLDFTEK EPRYEKICEG HDLDIPVERK
VELLKRANEK ARSYGDRVKQ VTVVLRDQIQ EVVVVNTTGQ IVEDLRPRVV FYTLVVASNG
IELQTGYEPV GHLGDYSLFE RVSPEEIASK AAERALTMLK ARPAPSGKFT VVLSSQAGGT
MIHEAVGHGL EADLANQGLS VYANKLGEEV ASPLITVVDD GFMKGKYGSS GYDDEGTPTG
KNVLIENGVL KGYMYDTLEA MKSGGMPTGN GRRQSYMHVP IPRMTNTYVA PGESDPQEII
KSTEKGILVV KMGGGQVNTV NGDFVFEVSE AYLIENGEVT VPIKGASLIG NGPQVLKEID
AVGNDLNFSI GTCGKDGQGV PVSDGIPTLR IPSITVGGTS
//
