ID E8T8G6_MESCW Unreviewed; 342 AA.
AC E8T8G6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:ADV10622.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:ADV10622.1};
GN OrderedLocusNames=Mesci_1463 {ECO:0000313|EMBL:ADV10622.1};
OS Mesorhizobium ciceri biovar biserrulae (strain HAMBI 2942 / LMG 23838 /
OS WSM1271).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=765698 {ECO:0000313|EMBL:ADV10622.1, ECO:0000313|Proteomes:UP000007471};
RN [1] {ECO:0000313|Proteomes:UP000007471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAMBI 2942 / LMG 23838 / WSM1271
RC {ECO:0000313|Proteomes:UP000007471};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Nandasena K., Reeve W.G., Howieson J.G., O'Hara G.,
RA Tiwari R.P., Woyke T.;
RT "Complete sequence of chromosome of Mesorhizobium ciceri bv. biserrulae
RT WSM1271.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP002447; ADV10622.1; -; Genomic_DNA.
DR RefSeq; WP_013529314.1; NC_014923.1.
DR RefSeq; YP_004140672.1; NC_014923.1.
DR AlphaFoldDB; E8T8G6; -.
DR STRING; 765698.Mesci_1463; -.
DR KEGG; mci:Mesci_1463; -.
DR PATRIC; fig|765698.3.peg.1905; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_5; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000007471; Chromosome.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADV10622.1}; Pyruvate {ECO:0000313|EMBL:ADV10622.1}.
FT DOMAIN 33..330
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 342 AA; 37061 MW; 052F428DD264173A CRC64;
MATASKAVTN SRANLPFVYR QYSAEQLKQV LHKMYLVRRF EEGAEECYTR GLIHGTMHLS
IGQEASAMGI CMPLAEDDQI TSTHRGHGHC IAKGAEVKRM FAEFFGKTTG YCKGRGGSMH
IADVGKGNLG ANGIVGGGIP IAVGAALSSK MMKTGKVVVS FFGDGANNEG AFHEALNMAA
VWKLPVIFVC ENNGYGMSTS TARSTAVKNI AERAAAYSMP GVIVNGNIFS EVAEASHQAV
ARARAGEGPT LIESKTYRHR GHSKSDRNRY RTKEEIEDWM SNRDPITLFE SELREFGFID
DKGIEAIRDA VAQEIAEGIE FAKASPSPDI SETGNYVYTE QA
//
