ID E8V3H3_TERSS Unreviewed; 259 AA.
AC E8V3H3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=NADP oxidoreductase coenzyme F420-dependent {ECO:0000313|EMBL:ADV83586.1};
GN OrderedLocusNames=AciPR4_2813 {ECO:0000313|EMBL:ADV83586.1};
OS Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Terriglobus.
OX NCBI_TaxID=401053 {ECO:0000313|EMBL:ADV83586.1, ECO:0000313|Proteomes:UP000006844};
RN [1] {ECO:0000313|EMBL:ADV83586.1, ECO:0000313|Proteomes:UP000006844}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC BAA-1853 / DSM 23119 / SP1PR4
RC {ECO:0000313|Proteomes:UP000006844};
RX PubMed=23450133; DOI=10.4056/sigs.3036810;
RA Rawat S.R., Mannisto M.K., Starovoytov V., Goodwin L., Nolan M., Hauser L.,
RA Land M., Davenport K.W., Woyke T., Haggblom M.M.;
RT "Complete genome sequence of Terriglobus saanensis type strain SP1PR4(T),
RT an Acidobacteria from tundra soil.";
RL Stand. Genomic Sci. 7:59-69(2012).
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
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DR EMBL; CP002467; ADV83586.1; -; Genomic_DNA.
DR RefSeq; WP_013569319.1; NC_014963.1.
DR AlphaFoldDB; E8V3H3; -.
DR STRING; 401053.AciPR4_2813; -.
DR KEGG; tsa:AciPR4_2813; -.
DR eggNOG; COG0345; Bacteria.
DR HOGENOM; CLU_066353_0_0_0; -.
DR OrthoDB; 9805754at2; -.
DR Proteomes; UP000006844; Chromosome.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR029036; P5CR_dimer.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR PANTHER; PTHR11645:SF13; -; 1.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF14748; P5CR_dimer; 1.
DR PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|PIRSR:PIRSR000193-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006844}.
FT DOMAIN 2..93
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
FT DOMAIN 151..233
FT /note="Pyrroline-5-carboxylate reductase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF14748"
FT BINDING 54
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
FT BINDING 67..70
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
SQ SEQUENCE 259 AA; 27712 MW; 4D0BE0A90B56F0CE CRC64;
MKLGFIGTGT IAAAIVKGLQ ASPAKCPVFL SPRNVEIARR LAERYANAQI AATNQAVLDA
SDTVILAVRP QIAHEVLTSL RFRPDHHVVS LIAAVSLKYL QSVTAPASIV TRAVPLPAVA
YRQAPTAMYP PNPTIKALFD ELGIVIELES EAEFDAFTTA TSIMSTYFGF ADTTASWMEH
QGVAPQKAHA FVGQMLRGLA AATTVAPDRT FAQMVEDHQT PGGLNEQVFR ALLPDGRLVE
LDRALDGVLA RLIAGKLKG
//
