ID E8WHM2_GEOS8 Unreviewed; 586 AA.
AC E8WHM2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Hydrogenase, Fe-only {ECO:0000313|EMBL:ADW13322.1};
GN OrderedLocusNames=GM18_1859 {ECO:0000313|EMBL:ADW13322.1};
OS Geobacter sp. (strain M18).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=443143 {ECO:0000313|EMBL:ADW13322.1, ECO:0000313|Proteomes:UP000001442};
RN [1] {ECO:0000313|EMBL:ADW13322.1, ECO:0000313|Proteomes:UP000001442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M18 {ECO:0000313|EMBL:ADW13322.1,
RC ECO:0000313|Proteomes:UP000001442};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Holmes D.,
RA Aklujkar M., Lovley D., Woyke T.;
RT "Complete sequence of Geobacter sp. M18.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002479; ADW13322.1; -; Genomic_DNA.
DR AlphaFoldDB; E8WHM2; -.
DR STRING; 443143.GM18_1859; -.
DR KEGG; geb:GM18_1859; -.
DR eggNOG; COG3383; Bacteria.
DR eggNOG; COG4624; Bacteria.
DR HOGENOM; CLU_018240_2_1_7; -.
DR OrthoDB; 9816402at2; -.
DR Proteomes; UP000001442; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.1780; -; 1.
DR Gene3D; 4.10.260.20; Iron hydrogenase, small subunit; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR InterPro; IPR036991; Fe_hydrogenase_ssu_sf.
DR InterPro; IPR013352; Fe_hydrogenase_subset.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR NCBIfam; TIGR02512; FeFe_hydrog_A; 1.
DR NCBIfam; NF040763; FeFe_hydrog_A6; 1.
DR PANTHER; PTHR11615:SF345; CATALYTIC SUBUNIT OF IRON-ONLY HYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 4..85
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 85..124
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 144..174
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 185..216
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 586 AA; 64151 MW; 8430E9B1EA09F99D CRC64;
MSIAQITIDG KTITMPAGST ILEAAKKLHV DIPTLCYLNL EHLKVNNQLA TCRVCVVEVE
GRRNLAPACA TPIVDKMVVK TNTIRVMNAR KTVMELFLSD HPKDCLVCQK SGECELQDLS
TKFGLRGSPY DGGAMSTYRK DFSESIIRDM DKCVMCRRCE TMCNDVQTCN VLSGVNRGFN
AVVAPAFEMN LADSGCTNCG QCVAVCPVGA LAEKDHTWSV IEALADPDKV VVVQTAPAVR
AALGEDLGME AGTLVTGKMV SALRSLGFDY VFDTDFAADL TIMEEGSEFL DRLTRFLAGD
QSVKLPIMTS CCPAWVKFFE HQFPDLLDVP STAKSPQQMF GAIAKTYFAE KLGIPREKMV
VVSIMPCLAK KYEAARPEFS VDGNRDVDVV LSTRELARLV KSSNIDFVSL PDGDFDLPLG
ESTGAAVIFG ATGGVLEAAV RTAYELATNK ELPKLDFSEL RGMEGVRVAK IPVGDQVLNV
GIAHELGNAR KLLDMVREGK EQFHAIEIMS CPGGCIGGGG QPYHHGDETI LEKRTKAIYR
EDVNKPLRKS HQNPYILDLY ENFLGKPLGE KAHHLLHTHY FKRKTP
//
