ID E9AF10_LEIMA Unreviewed; 328 AA.
AC E9AF10;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Putative 60S ribosomal protein L5 {ECO:0000313|EMBL:CBZ12814.1};
GN ORFNames=LMJF_35_1890 {ECO:0000313|EMBL:CBZ12814.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12814.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12814.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12814.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC {ECO:0000256|ARBA:ARBA00007116}.
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DR EMBL; FR796431; CBZ12814.1; -; Genomic_DNA.
DR RefSeq; XP_003722580.1; XM_003722532.1.
DR AlphaFoldDB; E9AF10; -.
DR STRING; 5664.E9AF10; -.
DR EnsemblProtists; CBZ12814; CBZ12814; LMJF_35_1890.
DR GeneID; 12982412; -.
DR KEGG; lma:LMJF_35_1890; -.
DR VEuPathDB; TriTrypDB:LmjF.35.1880; -.
DR VEuPathDB; TriTrypDB:LMJFC_350026200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_350025400; -.
DR VEuPathDB; TriTrypDB:LMJSD75_350024600; -.
DR eggNOG; KOG0875; Eukaryota.
DR HOGENOM; CLU_056222_1_0_1; -.
DR InParanoid; E9AF10; -.
DR OMA; CQIASAH; -.
DR Proteomes; UP000000542; Chromosome 35.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR GO; GO:0008097; F:5S rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd00432; Ribosomal_L18_L5e; 1.
DR Gene3D; 3.30.420.100; -; 1.
DR HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR InterPro; IPR005485; Rbsml_uL18_euk/arc.
DR InterPro; IPR025607; Ribosomal_uL18_C_euk.
DR PANTHER; PTHR23410:SF12; 60S RIBOSOMAL PROTEIN L5; 1.
DR PANTHER; PTHR23410; RIBOSOMAL PROTEIN L5-RELATED; 1.
DR Pfam; PF14204; Ribosomal_L18_c; 1.
DR Pfam; PF17144; Ribosomal_L5e; 1.
DR PRINTS; PR00058; RIBOSOMALL5.
DR SUPFAM; SSF53137; Translational machinery components; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000313|EMBL:CBZ12814.1}.
FT DOMAIN 268..323
FT /note="Large ribosomal subunit protein uL18 C-terminal
FT eukaryotes"
FT /evidence="ECO:0000259|Pfam:PF14204"
FT REGION 283..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 36605 MW; 238CE6C47A4A8DEC CRC64;
MCTLANWVRA IIKKHSTLAH TLEMPFVKVV KNKAYFKRFQ VKYRRRREGK TDYHARRQMV
LQDKTKFGSP KYRLVVRITN KDIIAQIVQA KIVGDEVVMA AYAHELPAFG IEHGLTNYAA
AYATGLLLAR RTLAKLGIAD KFQGAKEADG SYSAVRTKKD DEGDDEERFP FKAILDVGLA
RTTTGARVFG VLKGAVDGGM AVPHRPNRFP GYNKEKSSLD AKVHRDRIFG KHVADYLKQV
KEEASSNPDE KCVQFSKYMA AKVLPESIEG MYKKAHAAIR ADPSKSLPKK AKKEGVAHKS
YKTKKLSGAE KRAAAKAKVA AIRERLGK
//
