ID E9AZT3_LEIMU Unreviewed; 741 AA.
AC E9AZT3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Putative long-chain-fatty-acid-CoA ligase {ECO:0000313|EMBL:CBZ28484.1};
GN ORFNames=LMXM_28_1150 {ECO:0000313|EMBL:CBZ28484.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ28484.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799581; CBZ28484.1; -; Genomic_DNA.
DR RefSeq; XP_003876955.1; XM_003876906.1.
DR AlphaFoldDB; E9AZT3; -.
DR GeneID; 13450570; -.
DR KEGG; lmi:LMXM_28_1150; -.
DR VEuPathDB; TriTrypDB:LmxM.28.1150; -.
DR OMA; CLMLYTS; -.
DR OrthoDB; 5473537at2759; -.
DR PhylomeDB; E9AZT3; -.
DR Proteomes; UP000007259; Chromosome 28.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05941; MCS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43201:SF8; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:CBZ28484.1}.
FT DOMAIN 120..575
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 635..728
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 741 AA; 81791 MW; 76448F255A950EC2 CRC64;
MFRVFTSPIL AKVPYATLFE YNHVLKKVFE AQPSKVALRH EVPGMPEVQF TYGQLQRDVV
AMADAMVRRK EAVAQARGET SLSWLQPSRP AHVRSVFAQG ERTPSCDYMK DTGFYTTSVL
CGPGYTYAVS LLASWSLNQL VTPMSVSQRY KDELMYVLKH SGSRSIVGNT NLLKEKLPAE
YEELYVRAEV DIDKIPQSAS REPKLPENSS VTSNTFLVDT VYDATLLVRD ITAKRDTKET
AMLETEWLPP AKSACAPMQS AQDLVKRLDD EKAAAKAREL DRHAEIVQQE HLLRNRAPTE
ATGGAVPAGS DVDGDGLFCF DSGHLDGLNP VYQRWHAMPW ARPTKYDDCL MLYTSGTTAK
PKGVVHTHAS VTNMVKVLQD AWQWRDTDSI LHVLPWHHVH GLVNILLCAI ASNARCVVTT
FDDAARVAHR LEQGDITLFM AVPTVYAKLS DAVQRKFSPV EKTGFRKACM ESVRLMVCGS
APLPVPTLNQ FCELSGHTLL ERYGMTEIGM ALSQPLHPIS DRHPGTVGSP LPTVKTYVHQ
PETAEAMEQA SAKEAEYDEV GGLSIASESL FDRYWNNATA TKKEVRTNAA GMRFFDTGDT
VGVRLRARKP AVYTILGRST VDIIKSRGYK LSALEIEATL LARNDLFYEM AVVGAADAVQ
GESVVAVVAM QPEAARARGI AFGKGAAWCE SAAVTEELKK VALQLLAPYK CPSRYIVVPE
IPRNATGKVN KKELKKVLSL P
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