ID E9B4Y5_LEIMU Unreviewed; 277 AA.
AC E9B4Y5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Putative pyroglutamyl-peptidase I (PGP) (Cysteine peptidase, clan cf, family c15,putative) {ECO:0000313|EMBL:CBZ30304.1};
GN ORFNames=LMXM_33_2000 {ECO:0000313|EMBL:CBZ30304.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ30304.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the peptidase C15 family.
CC {ECO:0000256|ARBA:ARBA00006641}.
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DR EMBL; FR799586; CBZ30304.1; -; Genomic_DNA.
DR RefSeq; XP_003878752.1; XM_003878703.1.
DR AlphaFoldDB; E9B4Y5; -.
DR MEROPS; C15.012; -.
DR GeneID; 13452359; -.
DR KEGG; lmi:LMXM_33_2000; -.
DR VEuPathDB; TriTrypDB:LmxM.33.2000; -.
DR OMA; EVFHESW; -.
DR OrthoDB; 5490159at2759; -.
DR PhylomeDB; E9B4Y5; -.
DR Proteomes; UP000007259; Chromosome 33.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.630.20; Peptidase C15, pyroglutamyl peptidase I-like; 1.
DR InterPro; IPR016125; Peptidase_C15-like.
DR InterPro; IPR036440; Peptidase_C15-like_sf.
DR PANTHER; PTHR23402; PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED; 1.
DR PANTHER; PTHR23402:SF1; RE07960P; 1.
DR SUPFAM; SSF53182; Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase); 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
SQ SEQUENCE 277 AA; 30724 MW; FFBB259605896176 CRC64;
MLHSKAGIVV FITGYGPFAT VKVNPSSDIA LRVVEDLKRH PDVAEVRYTE LDVSVTAVAA
YFERVEREIA EIIAEHGAVK VKILLCHLGV HNDTTGLIRV EVQGYNELFA NVPDVDGKVL
NHEPIAPEDG PIEVFHESWF GKEGSPQFEK LESLIQEVND TIAESWHHSR TGAVTNNEMT
SVEPNRKDMM MPAFQAPSWA ISRDAGRYLC NCALYRALRL QERNPGVVYG IFIHVVDPIR
GKTEIEGGPI VAYNPTTMVQ SVQVKCLMNG LLSLMTS
//
