ID E9B6I7_LEIMU Unreviewed; 512 AA.
AC E9B6I7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=glycerol kinase {ECO:0000256|ARBA:ARBA00012099};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
DE AltName: Full=ATP:glycerol 3-phosphotransferase {ECO:0000256|ARBA:ARBA00043149};
GN ORFNames=LMXM_34_3080 {ECO:0000313|EMBL:CBZ30859.1};
OS Leishmania mexicana (strain MHOM/GT/2001/U1103).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=929439 {ECO:0000313|EMBL:CBZ30859.1, ECO:0000313|Proteomes:UP000007259};
RN [1] {ECO:0000313|Proteomes:UP000007259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/GT/2001/U1103 {ECO:0000313|Proteomes:UP000007259};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR EMBL; FR799587; CBZ30859.1; -; Genomic_DNA.
DR RefSeq; XP_003879304.1; XM_003879255.1.
DR AlphaFoldDB; E9B6I7; -.
DR SMR; E9B6I7; -.
DR GeneID; 13451020; -.
DR KEGG; lmi:LMXM_34_3080; -.
DR VEuPathDB; TriTrypDB:LmxM.34.3080; -.
DR OMA; FMLMNIG; -.
DR OrthoDB; 2734344at2759; -.
DR PhylomeDB; E9B6I7; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000007259; Chromosome 34.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07769; FGGY_GK; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR NCBIfam; TIGR01311; glycerol_kin; 1.
DR PANTHER; PTHR10196:SF69; GLYCEROL KINASE; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:CBZ30859.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:CBZ30859.1}.
FT DOMAIN 5..261
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 271..460
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 512 AA; 55771 MW; A2AB5EE9F1F7CA92 CRC64;
MPCVASIDQG TTSSRCIIFD ETFTILSAHQ LFHKQITPRP GWLEHDPEEI YSNCCLCLAE
ALKKLRSKDP KLAKVAAIGI TNQRETGVAW DRKTGKPLCN AIVWSDARTY EVSNRIATQC
GGGDSNFAAK ITGLPVSTYF TAFKFRWMLE NVPAVAAARK SGSLLLGTIE TWLLWKLSEG
KVFVTDVSNA SRTFLMNLRT QQWCDKLCQE LDIPRAALPE IRSNSERYCD VTANDHGIRD
ALGVPTPVTG CIGDQQSALF GHIGLQKGDA KNTYGTGCFV LMNVGAEPQF SKHGLLGTIA
YKLGTEPAKF ALEGSIAGAG ATVEWMRSNL GFFDHPMEME SIARKVSDTD GVVLVPAFGG
LLAPYWDPTA RGTLVGMTYK TNKSHIIRAA LEAISMQVNA VMLAMKEDSG VEINCLRVDG
GLTRSRLLME MQADILGVNL YVPHLTETTA LGAALCAGLA VGVWKSIEEV QKTAKDHLRG
ETVAPVTTDE QVRKARLDAW NAAVKLSQWA KL
//