ID E9CW14_COCPS Unreviewed; 1083 AA.
AC E9CW14;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=CPSG_01647 {ECO:0000313|EMBL:EFW21490.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL636487; EFW21490.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CW14; -.
DR STRING; 443226.E9CW14; -.
DR VEuPathDB; FungiDB:CPSG_01647; -.
DR VEuPathDB; FungiDB:D8B26_001681; -.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_005327_1_2_1; -.
DR OMA; DNAHRQC; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR InterPro; IPR019787; Znf_PHD-finger.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF102; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF16866; PHD_4; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFW21490.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 468..742
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..161
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 644
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 1083 AA; 120195 MW; 1E789BCFC656F262 CRC64;
MAATMPAEYE NATVEEDENM ADSEQDAEGE DDVDMYHPLT APGNFGGSEY VGTQHGLAEL
SAEPNHVNTV EETAQKVERT GALDSADINE NNGDNERVRP VKYLPVDYKS ESDADDAGDA
DPSFTNEESE SARDVVSNQS SDDDSEVDED WEAESDDRDS ADAEDLTLNN CIVCGQDEEH
DPSEEFEEPL VCAVCGDHCH RQCAREQECL NDADGKFRLW RSIVSNIAKE LLPAHSDALG
PDSHSIFDNP ILDDDPLDGS RSLRKRKASI DEVDNSRPLT RKRLRRTIDD QTDVAQANED
AGDRAPDNSN PSSRPSRPRR ARRSQNGLCS VVLRQHGRLV LSFHLDREKL SNVLKSRPRS
RTQRRRPPKP PVIPEEPPPP QFPPIISTPY TAPFYSFHEK EDHELNSKPY GGILADADAD
TSKTVPQQSD RDKFEVARQK AEEEWRQKIL AAEQSGEGSP QASQKLSGPP SKMKCINFGG
FEIETWYAAP YPEEYSRNRV LYICEFCLKY MNSDFVAWRH KLKCPVKHPP GDEIYRDGTI
SVFEVDGRKN PVYCQNLCLL AKLFLGSKTL YYDVEPFLFY VMTEYDELGF HFVGYFSKEK
RPSSSNNVSC ILTLPIHQRK GYGNLLIDFS YLLTRIERKV GSPEKPLSDM GLVSYRNYWH
LVLSYQLRDQ RTPTSIGELS ERTGMTPDDV VSGLEGLRAL VRDPVTKTYA LRLNYTYFEE
VIQNWEKKGY VQLNPDALVW TPYVMGRSNQ SHYDRAPLHA VAPRDDHEEA IDDGDINPFE
NGNGLSGLNK QSTNHDCGAI SGQNHVDSVP QFEAPGPPSM EVMSYGGQSM KHSNGYSTPS
VTSTIPSANI PPTRFEIFPP IQSAAVKRRP GRPFGSTKKT RPNATNASPV RTSGRNTPRK
NYNLTLATPT PAVRASPGLR RGRSKLLDNT LQTDGPADEP GYECVEPSNE DQDGSRSGAA
GVGDEDTQLK VNGEIHFDGD NVQDGARDTN ESKSTNGSVE ACQGPETNLV TRVKDQRDNV
SELESGDAAQ QLTADILAAS KIPTGKDGHT QNHPSHDERD TSQNGIGGER NFEAAPVSAS
AES
//
