ID E9CWM1_COCPS Unreviewed; 1076 AA.
AC E9CWM1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Sulfite reductase flavoprotein component {ECO:0000313|EMBL:EFW21697.1};
GN ORFNames=CPSG_01854 {ECO:0000313|EMBL:EFW21697.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2
CC reduced [cytochrome P450]; Xref=Rhea:RHEA:24040, Rhea:RHEA-
CC COMP:14627, Rhea:RHEA-COMP:14628, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:55376, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:60344; EC=1.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00036596};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; GL636487; EFW21697.1; -; Genomic_DNA.
DR STRING; 443226.E9CWM1; -.
DR VEuPathDB; FungiDB:CPSG_01854; -.
DR VEuPathDB; FungiDB:D8B26_001846; -.
DR eggNOG; KOG1158; Eukaryota.
DR HOGENOM; CLU_003662_1_0_1; -.
DR OMA; MIVAVNW; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR CDD; cd06207; CyPoR_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR19384:SF109; SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR Pfam; PF01558; POR; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
SQ SEQUENCE 1076 AA; 118489 MW; F1396B83B13BC4FC CRC64;
MRSIEPSSGG AAPEALGQEL DQTQSLTLPF GRLIPFSSIG GPTYVTAQTL IQHVAYTLSD
KLFAYSPETF DLDIAVRHWS SQSEPNANGY PTAVQTMETR QGAGSIALGY LFSKDFDLKK
RHIPQAIVAS SATLQYMRPA LEQLSLLYSV ANPLVAHVAA ADYVGGPSGG LVSDYSTAMG
LTEELGMALV TSQSVHESQH MALFSTLLAT YLPTIHIYDG LRVGRETTRV LDVLDRSGLH
NAYRSALAGL SGSDQKHLDT HGKLLNLLKS FNRELGTDYA PFEYYGHAEA TSVLVAFGTV
ECSLAKQVAI ALSKSDGRVG VVNVRIYRPF VEEEFARVLP KTTKIVGVLG QVQNDLAVQE
DGVHAPLYED VLAALMFSGG ISSRVECTEI KYSPRQIWDR GLITEAFQKI VGHQLERARG
VGADGVRLLD PLTKQYTFWD VDDSFSSTAA LVLGQALAKD SVFNVSAHTV YDNLTLGGTI
RTDIRKSAKV IDAPYSVDSA DVSYVGNIKL LSEIQVLKSV KPGGCVIVNA PGVKVDDLEK
KLPTEFKAAI ASQAIELFIL DTSDCQDPSL DPLILQIAFL RIALPDLELV GVKKLSLLLN
KETIVDKASS IIESMLRKIE IPQSWKGVGE TASEIEQLAT DIRGTSFAPF NKAEDEPSSE
LNDWQPVAKG LAFKEAYGAI NALRPDLPTK TYTVTVQENR RLTPATYNRN IFHIEFDLGE
SGLKYDIGEA LGIHAENDPE NVSDFIKFYN LNADEIVQVP SREDPEALEN RTVYQALTHN
IDIFGKPPKR FYESLAEFAT DVKEKEQLLK LGGADGAEEF KQRSEVDTVT YADILHEFPS
AHPSFHNLIK IVNPMKRREY SIASCQKVTP NSVTLMIVVV DWVDPRGRTR YGQASHYLSK
LKPGTTVTVS VKASVMKLPP KSTQPIIMAG LGTGLAPFRA FVQHRALEKA QGKDVGAVLL
YMGSRHQREE YCYGEEWEAY QAAGVITLLG RAFSRDQPHK IYIQDRMRET LPEITRAYLE
EEGAFYLCGP TWPVPDVTNV LEEAIAIHAK ANGKKVDTKK EIEKLKDDLR YVLEVY
//
