ID E9DFD7_COCPS Unreviewed; 1173 AA.
AC E9DFD7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=E3 ubiquitin-protein ligase HUWE1 {ECO:0000313|EMBL:EFW14794.1};
GN ORFNames=CPSG_08452 {ECO:0000313|EMBL:EFW14794.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL636503; EFW14794.1; -; Genomic_DNA.
DR STRING; 443226.E9DFD7; -.
DR VEuPathDB; FungiDB:CPSG_08452; -.
DR VEuPathDB; FungiDB:D8B26_000543; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_1_1; -.
DR OMA; AENSSWW; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 827..1173
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
SQ SEQUENCE 1173 AA; 132651 MW; ED734E02CD78B61F CRC64;
MAPSTSKADR SSPFPGGIIS ETISTLGPDD ANAAGDGRFL TRNDGRQILT FRPSLPTMSR
RTHSRSLSNP FPSLFGGRKK AEQHANQNSL LDVVDDESTQ LSRSVSPNRQ QDLNPPDHNV
IRRCMMCDHS NSFPSGKRGF RCGKCTTVND LEPCHSSRLL QIPSGDGKEA SGLAGKRKVS
VEKTRNIIDH CLRSFFSNQL KSLGLDPLTG PDLPVTRRRG ASESSLGTYR HEPPRHDAVG
DLSTKKAEPT FEFGKYPDGV CQSTIPQSPK ELPIQTKRKP VPSSSTVPSF DPQTHDQNQR
QNISRPTLQS GGYIFRVLED YIYASFDDCD TLNNSFLTPG SRHPRAASEG TPLRKSPENS
PSPPNGSPHF QLDGKTLRLG DIAENGSWWA GTRPTRHRSI NDNQNTRPNN THSGLVSFKS
PRINWPELSE WYHLVIHAGD CWRTAWHLMK PTNTDELLKW EAVELSGLEK LISESEFHLR
TVLLKATEKL LQRPKRPLER PEDTRFLLIL LVNPLLYPSS SSPRKPSAQL MVPGSGDRSR
SSMPADRVPV PRRSHSALSN KAIAPSDRRS VIIKRIIGLL SNLPGECHHS LVSWFSRLSE
NQFRRLVDLV GSFVTYRLSK GSRRRPSKSV NIEDNIEEFV PTFSGPSSTT SAQLHSALQR
DNATKPSSSE HKTVAYSDDW QMRAAARVMA LLFRANHSSH RRRSPHSASY PPLNGQHEVH
DHLHMIPIST FYNTLLDYSD LITDFEAWES RTGKFTFCQY SFFLSIWAKI RILEHDARRQ
MEAKAREAFF DNILGRRGTS QYLVLKVRRE CLVEDSLRGV SEVVGSGQEE IKKGLRIEFV
GEEGVDAGGL RKEWFLSLVR EVFDPLNGSF LYDNDSRYCY FNPYCFESSE QFFLVGVVLG
LAIYNSTILD VAFPPFAFRK LLASARPNNV PTLSTPYQPF RCTLDDLAEY RPALAKGLRQ
LLEYDGDVEE TFCQDFVIQV ERYGETIEVP LCPGGEKRPV TNSNRWEFVD LYVKYMLDDA
VSRQFEPFKR GFFTVCGGNA LHLFRPEEIE LLVRGSDEAL DIPSLRAVAV YEHWPTANPD
RDPVVNWFWE FFTRVNPQDQ RKILSFITGS DRIPAMGATN LVICLLYLGQ DSERFPIART
CFNMLSLYRY KTRQKLESKL WRAVVESEGF GLK
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