ID E9DFF1_COCPS Unreviewed; 913 AA.
AC E9DFF1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ras guanyl-nucleotide exchange factor RasGEF {ECO:0000313|EMBL:EFW14808.1};
GN ORFNames=CPSG_08466 {ECO:0000313|EMBL:EFW14808.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL636503; EFW14808.1; -; Genomic_DNA.
DR STRING; 443226.E9DFF1; -.
DR VEuPathDB; FungiDB:CPSG_08466; -.
DR VEuPathDB; FungiDB:D8B26_000531; -.
DR eggNOG; KOG2378; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OMA; HIAKWVA; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
SQ SEQUENCE 913 AA; 102442 MW; 514FCF33ED356313 CRC64;
MTPQHLRNKS AGDLIKKQPV PPPQRPTLQS RTYSAPAGEL PRPRHSKQPD GIIAAIDESN
PLPYAQDASG HIPNETMVSI PSQHCLPQVN MAVVGAQGVG KSTLVKYALD LKQTPIARSS
VKKMSLDGTI YLVRLLEVGI HNIAVDEHGR ITWPRLLGEQ ALPPIDGVLA LFDSADPRTL
TQLSQLLSAL QQTSSIPFLV VACKCDTPRR SSQHDPAVLE QANRLLAGTE ALQTSIRVSE
SYKKCISIVL RAIIVRTSDV VSEKKRPLPK NRASSGNIPS RLRPYSSRQH TRAHSETPKG
TCLHAADPYL NEGVRLDSAT DSNLALNVHG SRYGRSNSQP VPPRTPPGNR VNRGSSLTVD
PVPEETSPGN IAHQRLRTQW RHSAGSDAFN SFLDMEDETE DSSNQLTSPS SPNAKTKPED
PGSTFDELVD RLLSMPLTKQ DAKFPSIFLC LYRKFASPSQ LLYSIIGRFE RMENSGVPRL
KRHADQLTML NVLAQWAAEY PGDFASPKPR KRLTDFIGFL EKNMIFAFAA KEISSCLEKF
VEDDDVDWAF KDEKGEPENV ETFLDTSVQS SPAASVSQNT DETIQNMAAL DLNEENVDHA
SQYSNLSMTS TLNRSGSISS QSFKMLLGTE SAHREAQRLE IVPRHTLGKT QWRIFMEIPD
EDFARELTRI DWVMYSAFRP RELIRHVSTS SENKEKPSSH LENVNRMIKQ FNHLAYFAAS
MVLLRDKAKH RAQALEKFMN ISLKLRQLYN YNSLGAIIAG LNGTPIYRLA QTRALVSHSV
TKQFMSLVIL MGTQKSHFAY RLAWENSFGE RIPFLPLHLR DLVSAEEGNR TFIGDRINWR
KFEIMGDVIL GVQQSQKTPF PTFHINEIVR RLVLEAKFES DEEELYTRSL QVEPSAVVGG
GHERHKRFNW RRN
//
