ID E9DR08_METAQ Unreviewed; 2200 AA.
AC E9DR08;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EFY93686.1};
GN ORFNames=MAC_00177 {ECO:0000313|EMBL:EFY93686.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY93686.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY93686.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698470; EFY93686.1; -; Genomic_DNA.
DR RefSeq; XP_007806517.1; XM_007808326.1.
DR STRING; 655827.E9DR08; -.
DR GeneID; 19244488; -.
DR KEGG; maw:MAC_00177; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_0_1; -.
DR InParanoid; E9DR08; -.
DR OMA; INHGWER; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR030918; PT_fungal_PKS.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR04532; PT_fungal_PKS; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 386..822
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1688..1765
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1809..1886
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1762..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2200 AA; 239791 MW; 6443754262AD875D CRC64;
MTLGPPSLLQ GHEPQKYEVL LFGDLSASGF EEDLRRLLHI KTDPLLSSFL EQAGLSLRRL
IGNLPSRQQD LFPRFTTLID LVSWLESTPG APVLKFFALC VYEIAQFIVK YGSNSKSYPS
STGTCIIGPC TGGFAAAAIS CSQTLSDLIP VAVQACLAAF RTALRSWLAG QDLSPHQPSD
TSSWSAAVRP KELNESVESL LKELDTSVTH REQARLYISV TTPDHPTTIS GPPSSLREFL
SKASERLRSR YLDIQSPFHT SSLFDELDVD TIVSQVSELA AIHVPRIPIL SSSTGEVITA
PSFKELLRLV VDETLRQPIR WELVASSCRS LLAEAKAEEC TIITFSSLAA SMLRNALAVG
EDNEVSVEHA AQEQHQSASS SGSFAHSKIA VIGYSGRFPD AASNEAFWEL LRAGRDVHRE
IPADRFNWET HFDPTGKRKN SSRVKFGCFI EEPGAFDAHF FHMSPREAEN TDPAQRLAIT
ATLEAIEMAG LVRNRTPSTQ QDRVGVFFGT TSDDWREVNS GQDVDTYFIP GGNRAFVPGR
ISYFFRFSGP SLSIDTACSS SFAAIQTACS YLWRGECDTA IAGGTNILTN PDNFAGLDRG
HFLSRTGNCN PFDDEASGYC RADAVGSVIL KRLEDAEADN DPIFGVIVGT NTNHCGQTDS
ITRPHEGDQA SVFKRIMRYA NIDPLDISYI EMHGTGTQAG DMTEMNSVLS VFVPETKRTL
SEPPRPLYIG SAKANIGHAE SASGVSSLIK VLMMMKNSEI PPHCGIKTRI NRNYPLDLAE
RGVHIALSPT PWLRENSVSG KRSVFLNNFS AAGGNTAILL EDAPQTTRPP DAEQDPRPVH
LVAVTAKTKA SLLGNLTALS KWIEEDPNIS LSHLSYTTTA RRMHHNYRVI VSGSDIPSIL
SSIKMKLSAL SQTSIKPIPP LAKAPNLVFV FTGQGTLYTG LGKSLYLTNA SFRSSILRFS
RLAQDQRFPS FIPLVDGSHP MGNAEEISAV VSQLAITSVQ MALFELWCSW GLTPSAVIGH
SLGEYAAMYA AGVVNAADVI YLVGHRAVLL EERCVPGANA MLAVKANSDS VMQLTRNTGC
EIACVNQPTG HVISGPIEDI SRSESKAAAA GLETVRLELP FAFHSAHVEP ILVPFKAAAS
QGVTYSAPTF PIISPLESRV VPAGEIGVFD ASYLVRACRR TVDFRGALEA ARNDGLVNER
TLWLEIGAHP TCSGMIKGTL GAEYSALASM RKNVDAYKSL VPSLESLYLS GFNIAWNEYH
RDFPSAKRVL ELPRYSWDLK NFWIHYRNDF CLAKGEGLVP ASGGEVPPQQ ALNAPNIPQY
KYLSPSVQRV LDEAHDTRLS SLLIESDVFH ETLLPVFQGH AVNGVQLCPS SLYADIALTM
AQHMLQGPGL SPSTTGLDVA DVKVDAPLIA QPAEKEHLFR VSAKAVWSEN TITMSIFSVN
SKGQRTTSHA NLEVRVVPEQ RWIDHWKRNT HLIMSRIEAL NQGINGGNSH KMKRGMVYKL
FGAVVEYSKE YQGMEEVVLD SERLEAVSTV KFQVAEDGFV INPRWMDSLG GIAGFIMNGN
DAVESKKQVF INHGWERLRI AEKLDQAKTY YAYNRMQRAE KTMYVGDTYV LHEGRIVAVV
EGVKFQGVPR HVLDHVLPRQ SSDISPSSSL AKQGHAFHGT QEKVVTVLDQ KLRKASTEGA
LKSEHKVGPS STLLGKVLAI ICEEVGLSLV ELQPESEFAN IGVDSLLSLT ILARAREELQ
ADLSASLFVD YPTVGSLNAL LGTQTPDSGD DVQTPDSRCD SPTTSSIGIT DITTPVSGIK
LDVSSGFTDR VNETLGILRS AIAEETGVSL VDLDPSTGLA DIGIDSLLSL TIVAKVSETF
GDSIPRDLFA SHTTLQEVEA AVLSSLGLNE KKGKQATPQA FSEPQGHRLQ APFHDSRGFG
NDHSALSSPP NATSILLSGS AETARSLLFL LPDGSGSASS YAALSRSIGR GIAVYGLNCP
WRKTAEEMTR LNIDMAALAE KYVIEIQRLL HQRSNSSTRP VRFAIGGWSA GGIIAVEAAR
VLRRLGQNVD KLILLDSPNP IGLQNPPERM YDFFDSIGIF GGGRNKMPEW LRSHFREFIH
ILDKYEPTAL PDAPPTLLVY ARDGVCKDPN GPRPEMHPDD PREMLWLLNN RTDFSAGGWS
SLLGRKNLTI RVVDDVNHFS LMDPGPAMKT LGGIIEGYLS
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