ID E9DSA2_METAQ Unreviewed; 1349 AA.
AC E9DSA2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=MAC_00500 {ECO:0000313|EMBL:EFY93262.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY93262.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY93262.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698471; EFY93262.1; -; Genomic_DNA.
DR RefSeq; XP_007806840.1; XM_007808649.1.
DR STRING; 655827.E9DSA2; -.
DR GeneID; 19244811; -.
DR KEGG; maw:MAC_00500; -.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_001832_4_0_1; -.
DR InParanoid; E9DSA2; -.
DR OMA; LFRVCNM; -.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EFY93262.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 274..315
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 594..770
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 831..996
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 187..214
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 150952 MW; 7148DC232A7B8E63 CRC64;
MVKKGKAKAE LPTQALESAG NSGTKTKKGQ KSESSTPSVP PAGPPKPTVK QIIGGSSWTG
KLPVNLLSEH CQKQRWEKPE YDTRKTPEGF SVWVTLSAKD PKTQQMTKLD PFKIPLSHKH
LILRETALEA KHAAATYALF RVCSMQNKHT VLPPDHKSLW KEFQALKVQD VKDGKAWMYE
ADPFKALQER QEAKAAADKK RRELEQAKAK AKEMPGASGL VLLSNSGNDK GTSFNPMKGW
TTAPKVEMGR QTRVQLEALL RNGISWNPRR VRMQQDQKNS LVTELGKLGF RRSHIIEAVE
YCKDREETLE WLLIHVPEDD LPRWAIPESY SAGVSIGSTN LKREGIIKSL SETGYSVELC
SRILDGNDGD ESKAAEALQQ ILLSSNSASD AGKGEPDDFL DMGSPEEQWE EEIASLEAMY
GDAFRRESSD LIQLKLESVK NAQNGQEGEV ETFLQVRRPS SYPKHLIIAI IAKLPSYIKL
SIVRRALAYM ENSLRDEPMK IYLVMDWIQQ NINGIIDSPG NLVDISAVSS AASENRPIAQ
GGRVKRTRNV RPINWIPDFR TKEEWLQRQE SSAWKDMLSK RQRLPAWQMR EKIVKTVKDN
HVTIISGETG SGKSTQSVQF ILDDLYGKGV GGCANMIVTQ PRRISALGLA DRVAEERCSK
VGGEVGYIIR GESRQSKDTR ITFVTAGVLL RRLQTSGGRV EDVVASLADV SHVVIDEVHE
RSLDTDFLLN LIRDVMRTKK DMLKLILMSA TLDASTFMDY FATEGLSVGC VEIAGRTFPV
DEYYLDDVIR MTGFSVEKPD AGFITDESMG KIIQKLGHRI NYTLLVDAVK AIDYELSYEK
KPDGILIFLP GVGEINHACN LLRSINSLHV LPLHASLETR EQKRVFSKPP PGKRKVVVAT
NVAETSITID DIVAVIDSGK VKETSFDAQN NMRKLEETWA SRAACKQRRG RAGRVQEGRC
YKLYTENLER QMAERPEPEI RRVPLEQLCL SVRAMGMRDV ARFLGRSPTP PDAKAIEEAI
KLLRRMGALD GDELTAMGQQ LAMLPADLRC GKLMVFGAIF GCLDDCVTIA AILSTRSPFL
APQEKREESR QARMRFFSGN GDLITDMEAF REWDSLMRDR LPQRQVRSFC DENFLSYQTL
SDISNTKSQY YEALNEIGLA PRFRSDGATS NSVRNVQLIR ALIASAFTPQ IARIQYPDKK
YASSMSGAME LDPEARSIKY FNQENGRVFV HPSSTVFDSQ GFSGNAAYMA YFSIISTSKI
FIRDLTPFNV FTLLLFSGPI ELDTLGRGLL VDGWLRLRGW ARIGVLVARL REMVDDLIAQ
KVEDPGLNLD NNKVIKLVIK LIELNGLDA
//
