ID E9DVV6_METAQ Unreviewed; 1357 AA.
AC E9DVV6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=MAC_01754 {ECO:0000313|EMBL:EFY92153.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY92153.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY92153.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
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DR EMBL; GL698477; EFY92153.1; -; Genomic_DNA.
DR RefSeq; XP_007808094.1; XM_007809903.1.
DR STRING; 655827.E9DVV6; -.
DR GeneID; 19246065; -.
DR KEGG; maw:MAC_01754; -.
DR eggNOG; KOG1907; Eukaryota.
DR HOGENOM; CLU_001031_0_2_1; -.
DR InParanoid; E9DVV6; -.
DR OMA; LSANWMW; -.
DR OrthoDB; 2891567at2759; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 38..155
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 179..228
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 446..598
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 881..984
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1190
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1357 AA; 147854 MW; 6D190DC1EF0EED68 CRC64;
MPHDILVGSS CYTATSAQEI KARANKTSQP KIQQIRGQWV YFVDLKSSSK AVLEKVKTLL
QDVDSEPLLA SESTSNTITV YVTPRYLSPW SSQATNIAHV CGLKEQVNRI EKGRLIVIDF
EEPYQTGQDA TFRDVLYDRM TEIFSFEKPE LDVMFAAGVP APLVVVDIFA DGKDPLIVLR
DYNKEKGLSL DESEMAYLVD VFKKLGRSPH DVELFMFAQV NSEHCRHKVF NASWTIDSVK
KNNSLFEMIR NTHKKTPDYT VSAYSDNAAV LQGESANFWA PDYSTGTWTM TPEVAHILAK
VETHNHPTAI SPFPGAATGS GGEIRDEAAV GRGSVTKGGL AGYWVSDLLI PDHRAPWEVD
IGRPSHYASS LDIMLEAPIG SARFNNEFGR PCLTGCFRTL LTPETPTEDA KAEASAWRGY
HKPIMLAGGV GTVRPSNALK EERFVREGAH VIVLGGPAML IGLGGGAASS NASGESNADL
DFDSVQRGNP EMERRAQMVI NTCTALGEQN PIAMIHDVGA GGLSNALPEL VKDAGFGGNF
ELRQVESADR SMSPLQIWCN EAQERYVLLI NPENMNRFTS ICRRERCGFS DVGAVATKDA
NGDARLILTD RESKEYPRPI DLPMDALFPP KHQQERNVSS KKPNLTPFDA LASLRKAFGA
DLDNATLLKN AVERVFLMPA VGSKSFLITI GDRTVGGLTA RDQFVGPWQT PVADVAVTAT
SFSLGGKQRT GEAMAMGEKP TLALINPAAS ARMAVAESLM NIGAADVMGD LRRVKLSANW
MAAVSHPGEG AALYEAVEAI GMKMCPEISV SIPVGKDSTS MKAVWKEQNE VKSVTAPVSV
AISAFAVVED ILSTWTPQLR RVEEVGESIL MFVDLAEGRR AMGGSALAQS LGAIGNEAPD
MKNFNLITDY FDALSQLHKS GVVLAYHDRS DGGLITTIAE MMFAGRCGVD MMMDGISKSG
SASDMVEALF NEELGAVFQV KASDEINFKR CFATCGPPPG LIRKFGVVKA SPNQSLTIRH
GATTFANLDR AEMQQWWSKT SHQMQRLRDN PACADSEYAT ISDVSDPGLS YHLTYSPSEN
ILPLTSSITG FFNKTPRVAV LREQGVNGHA ELAFAFRAAG FEPVDVHMTD VLGGRSLADF
TGIAAPGGFS YGDVLGAGQG WARSVLMHES TRREFEHFFR RPDTFALGVC NGCQFLTRIQ
ELIPGTEHWP TFVHNESAQF EGRYSMVTIK EDESKPSVFF HGMNGSSLPV VVSHGEGRAK
FSSPNSLQEL TNSGMIPMRY VDNRLKVTEK YPYNPNGSPG GVAGVSSKDG RFVAMMPHPE
RTIVAGVNSY IPPKATEEWG DFGPWVRIFK SVRRWVG
//
