ID E9EJ72_METRA Unreviewed; 1742 AA.
AC E9EJ72;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Rho guanyl nucleotide exchange factor {ECO:0000313|EMBL:EFZ03758.2};
GN ORFNames=MAA_00832 {ECO:0000313|EMBL:EFZ03758.2};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFZ03758.2, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFZ03758.2, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFZ03758.2, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ03758.2}.
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DR EMBL; ADNJ02000007; EFZ03758.2; -; Genomic_DNA.
DR RefSeq; XP_007817021.2; XM_007818830.2.
DR GeneID; 19255118; -.
DR KEGG; maj:MAA_00832; -.
DR HOGENOM; CLU_001083_2_0_1; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 922..1114
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1149..1311
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1378..1686
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1742 AA; 191935 MW; 3CF4E067616FA375 CRC64;
MSFRGDDQRR YGSVPPVQYT VAGQQDQHGT HQATSASGVG RRPSFNTGDD AGYYTQNHNR
TASFTRGEDE LFLTGPVGRG GNVPVNRYAS TSSAMAGYQH QYQDPTPPTP SQSGYNPQSF
SPSSNSAYHR SQASTLPYHS AQRFSTSSAG SYHTPSPPAT NYTPQAYNPA AYAATNSFPQ
RQASHHGYGY AAHDQGYAAG VGTAGSPSYG HSPSASHTST FSQPVRSPSF SSSFQQSFPT
SPSSFTGSNP MSQTPTYDPS NYHSSTQYSS YGSNGVAPYP SSTSQTQAPY PNSSHNPVGP
NYTASNDQHS YFTRHPSDSQ SSPRTSPYMQ AQSSPGLQRH PTNAPLPSRP MEDVPEETTP
WDEHGRPLAN DDVDEERIAQ ETIMQDIEAE LGGSGYHSQR RPSPIGSQAF DDQTQRLRGY
SSASAHSPGS RTSPGRGSSR PRFDDDDDDD DPEGTAGLLA MQQAELDDQR FGGGTFMYCG
TDPAPAAPLP TTMAAPTTTI QSNFPAPPPE ELNHSSDSDL GGMDIGMLSG DIGSPPGSSS
MLDGPRPLPT PGYYNSLRES YDHAAAFNNA GMDYVGTGGL QAPEAHRLSF DEGGEERVSI
HSQHSGTESP TRDDYQDLFY HPGLSNRPLP ALPPGPGSDS SSMLSVHNSV RSQHQHDHSI
NADARYYQAD GPETFYQHGA QQTLHPERSV SLGGRSHTPQ IQAPARSRTD AAEERKKMNR
NHQITQQSPA FDYDRAPVAA SGAFDSITLP SGRKRRFVPS KLTSSDFNDC KAPWALSHIE
TWIRNMGEGE PDLKEKAIEE AVTNLFVYKI PTMNVADAEA LSSQVVSGML ESQVLLPDEE
WVKFGDGHIS GVLWQLTGSG CYAPKLHDVE MSGRCYSHYC TRTLKKVDLE VLSEEVQGAD
AWHTFYKLTK EVVDSKPKKE VERQNILHEI VTGEENYIKQ LDIFRRLYRD DLRTRAPPII
HPDKRDKFLT AVFGMLDTVV HINKDHLLAQ LKYRQQEQGP WISGFSDLFR EWIRKAKSVY
TEYAIGYPRA AYMVRKEADR NLLFKRFLED KQKDKLSAKQ DWTHFLITPV QRLQRYILLL
QSVEHKMIGD SEEKTNLAKA IQEIQTVTLE CDAKVAETNK RVQMMELDRM LVLRPGFQSV
LNLDHLGRVL IMQGELQRMG SKGMRWVDSH ALLFDHYLIL AKVVVPKDGK GERKYDVSRE
PIPMPLLFLE SMNDEPVMKQ KGLTAPLGRA TAAPVGAQLN KVASNGAGRP GLEHTPTAPG
NTLVPTTSND TEGKILYPFK VKHLGHEVYT LYASSARDRL DWCNSIIEAK TRHAKALYAQ
NAEPFRLRVL ADAAFHYDTG SVYARASGVP VKGTPLDRAI QDLDKVLGSA QGTAAVCRAQ
VNCATGFSAF GKSVIAIGTD YGVYISDSSN PRGWTRSVQI SRVTQIAVLE EFSVCLIIAD
KSLICYPLDV IAPVSEFAAP VNDNTRRAPQ RLAKDVTYFA TARMKDRLLV FYKRKEGMHT
SFKVLEPIFH KATEKKSRLF GGRKSGGGST DTFRDFDEFY LPTDCYSLSI FQTYIAVATS
KGVEMLTLDK KQPMSIPDLK THGIANIAGR IREQKPLGMF RLDTNEFIVT YEDCAVYVDK
HGEVSRTLIM EYTGKQKKAK GATTYKQYLL LFNEDYVEVR NAGNGRLRQI IAGRDVRVID
FGLGGPTGGN AAQSQQTYGP NGQSLLAGDT SKGSVKIAMC HPELPGRQIV LELLLNDGHC
EG
//
