ID E9ETP6_METRA Unreviewed; 688 AA.
AC E9ETP6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Sterol esterase {ECO:0000313|EMBL:EFZ00799.1};
GN ORFNames=MAA_03395 {ECO:0000313|EMBL:EFZ00799.1};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFZ00799.1, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFZ00799.1, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFZ00799.1, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFZ00799.1}.
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DR EMBL; ADNJ02000003; EFZ00799.1; -; Genomic_DNA.
DR RefSeq; XP_007819584.1; XM_007821393.1.
DR AlphaFoldDB; E9ETP6; -.
DR ESTHER; metar-e9etp6; Acidic_Lipase.
DR GeneID; 19257681; -.
DR KEGG; maj:MAA_03395; -.
DR HOGENOM; CLU_024238_0_0_1; -.
DR OrthoDB; 5471104at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR PANTHER; PTHR11005:SF160; STEROL ESTERASE 1-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 167..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 268..348
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77969 MW; 84D97F9B231214B5 CRC64;
MAKPSRAKKP SGQKVYRAPS HELTQLGVQT KGQAGKTTQQ DHTGRTGSVS MAAKALFAGP
ALNSLQNNGK LPNFPLRATT RVADEANGFV PDGESHEKGA EVEHAEAPSS LNNGVPGLQT
SARLYYSADE ETRPNNQDDH YPSQINPLFP PLPLYSHPSF KTRLQYLVFR FSAAVLSLSF
LCFIVVGSLI TSIPKLIKKI IYKSTQRDVR KLRPFYEEEL RRADIRKQKQ KAWDHRTSAE
KIGGDQEGTA DEYPPTEGGR DKIVCDVGYY ARRVGLDVDM FKVRTEDGFL IDLWHVYDPK
EYTILNTDAE TSDTNSPRKM LRPGDKKTKF PVLLMHGLLQ SSGAYCSNDD DSLAFWLCKS
GFDVWLGNNR CGFSPDHESL STADPRMWCW NIRQMGIFDL PALTAHVLAE TGFDKLGLVC
HSQGTAQTLI ALSKDQCPTL GEKLTVFCGL APAAYAGPVI DKFYFKFMRK ISPFWFQFIF
GIHAFIPFMM QMHSFMNPTV FGWLGYKVFS FLFDWSDARW DRGLRNRLFQ FAPVYVSAET
MRWWLGRDGF ARHKCILSTE EVLRFEEQQD NNGLHNGSSP ASRQWYNELA PPFAMWVCGN
DQLVDGKRLL RRFTSGQEPH VKMIHSKVIE DYEHLDVIWA IDAVEQVFVE IREVLWKTCH
ARDRCRVPEG CEAIPAWAPE IESTTAVI
//
